{"id":"efff41f1-878c-5ada-9249-589bacdadca5","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-wholeblood-erythrocyte-thdp-correlation","predicate":"correlates-with","statement":"HPLC whole-blood and erythrocyte ThDP measurements correlated at r = 0.97 in the study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"98b00ef9-22ef-576e-b254-6cd830d0370a","mechanism_event_label":"Whole blood and separated red cells gave closely related ThDP results under this method.","subject":{"id":"97206826-3d6b-5466-ab3c-407351eb0c93","slug":"whole-blood-thdp-concentration","display_name":"Whole-blood thiamine diphosphate concentration","entity_type_key":"cellular_process"},"object":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"98b00ef9-22ef-576e-b254-6cd830d0370a","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-wholeblood-erythrocyte-thdp-correlation-event","event_type":"observed_intervention","label":"Whole blood and separated red cells gave closely related ThDP results under this method.","description":"HPLC whole-blood and erythrocyte ThDP measurements correlated at r = 0.97 in the study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"187db168-8028-5ce6-9f8b-4bc61ebad1a0","slug":"thiamine-diphosphate","display_name":"Thiamine diphosphate","entity_type_key":"small_molecule"},"role":"measured analyte","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"97206826-3d6b-5466-ab3c-407351eb0c93","slug":"whole-blood-thdp-concentration","display_name":"Whole-blood thiamine diphosphate concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Whole blood and separated red cells gave closely related ThDP results under this method.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[talwar-2000-blood-thdp] Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay (2000). https://pubmed.ncbi.nlm.nih.gov/10794754/ DOI: 10.1093/clinchem/46.5.704","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole blood and packed erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"42d75406-7bbb-558f-a032-625a30827db9","evidence_kind":"source_excerpt","locator":"Lines 1409-1421","start_line":1409,"end_line":1421,"excerpt":"### thiamine-def-wholeblood-erythrocyte-thdp-correlation\nHPLC whole-blood and erythrocyte ThDP measurements correlated at r = 0.97 in the study.\nCondition category: biomarker_context\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Whole blood and separated red cells gave closely related ThDP results under this method.\norganism: Homo sapiens\ntissue_or_cell_type: Whole blood and packed erythrocytes\nexperimental_model: Human method-comparison study: HPLC erythrocyte/whole-blood ThDP, healthy reference cohorts and 63 patients considered at risk of deficiency compared with a transketolase activation test.\nlimitations: Correlation is not identity or a tissue-deficiency threshold; reported reference intervals were normalized to hemoglobin and are method-specific.\nevidence_location: Abstract Results\nevidence_span: correlated strongly with that in whole blood\nexposure: Laboratory assessment of thiamine status using erythrocytes or whole blood\n[talwar-2000-blood-thdp] Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay (2000). https://pubmed.ncbi.nlm.nih.gov/10794754/ DOI: 10.1093/clinchem/46.5.704","model_system":"Human method-comparison study: HPLC erythrocyte/whole-blood ThDP, healthy reference cohorts and 63 patients considered at risk of deficiency compared with a transketolase activation test.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [talwar-2000-blood-thdp] Vitamin B(1) status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay (2000). https://pubmed.ncbi.nlm.nih.gov/10794754/ DOI: 10.1093/clinchem/46.5.704","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}