{"id":"efbd8a62-70d9-567a-b107-0a48bfb90059","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-samtor-specificity","predicate":"enables_sensing_of","statement":"SAMTOR loss made mTORC1 resistant to methionine starvation while leaving leucine- and arginine-starvation sensitivity intact.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff9c545d-d792-5b8a-b543-9c26725506f4","mechanism_event_label":"Different amino acids enter the growth-control network through different sensors.","subject":{"id":"0aadc8c9-0495-5791-baff-c975275a21e3","slug":"samtor","display_name":"Human SAM sensor / SAMTOR","entity_type_key":"protein"},"object":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ff9c545d-d792-5b8a-b543-9c26725506f4","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-samtor-specificity-event","event_type":"observed_relationship","label":"Different amino acids enter the growth-control network through different sensors.","description":"SAMTOR loss made mTORC1 resistant to methionine starvation while leaving leucine- and arginine-starvation sensitivity intact.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0aadc8c9-0495-5791-baff-c975275a21e3","slug":"samtor","display_name":"Human SAM sensor / SAMTOR","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f707c753-cc8c-5f06-90be-bb3d73c60a18","slug":"leucine","display_name":"L-Leucine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"9f025af3-f039-517f-908b-4af6fc65415e","slug":"mtorc1","display_name":"Mechanistic target of rapamycin complex 1","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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