{"id":"efab5566-34a6-5146-9e30-1b356f726497","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclophilin-cyclosporine-inhibits-calcineurin","predicate":"inhibits","statement":"The cyclophilin-cyclosporin A complex competitively binds and inhibits the calcium- and calmodulin-dependent phosphatase calcineurin.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"33663a8b-898a-508c-bace-f59c3c04c121","mechanism_event_label":"The cyclophilin-cyclosporin A complex competitively binds and inhibits the calcium- and calmodulin-dependent phosphatase calcineurin.","subject":{"id":"90dbcd2a-88d9-5a7f-85b2-5372761d4b4e","slug":"cyclophilin-a-cyclosporine","display_name":"Cyclophilin A-cyclosporine complex","entity_type_key":"protein_complex"},"object":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"33663a8b-898a-508c-bace-f59c3c04c121","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclophilin-cyclosporine-inhibits-calcineurin-event","event_type":"biochemical_relationship","label":"The cyclophilin-cyclosporin A complex competitively binds and inhibits the calcium- and calmodulin-dependent phosphatase calcineurin.","description":"Calcineurin phosphatase activity","status":"provisional","compartment":null,"participants":[{"entity":{"id":"90dbcd2a-88d9-5a7f-85b2-5372761d4b4e","slug":"cyclophilin-a-cyclosporine","display_name":"Cyclophilin A-cyclosporine complex","entity_type_key":"protein_complex"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified mammalian proteins","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cyclophilin complexed with cyclosporin A","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Binding and inhibition of calcineurin did not require calmodulin in this report. The inhibitor is the complex, not the drug, so this arrow must not be redrawn from cyclosporine directly to calcineurin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Purified mammalian proteins","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cyclophilin-cyclosporin A complex competitively binds and inhibits the calcium- and calmodulin-dependent phosphatase calcineurin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. (1991). https://pubmed.ncbi.nlm.nih.gov/1715244/ DOI: 10.1016/0092-8674(91)90124-h","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Calcineurin phosphatase activity","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3595db09-a598-5342-b3ef-b8761529987f","evidence_kind":"source_excerpt","locator":"Lines 47-47","start_line":47,"end_line":47,"excerpt":"The cyclophilin-cyclosporin A complex competitively binds and inhibits the calcium- and calmodulin-dependent phosphatase calcineurin.","model_system":"Purified mammalian proteins","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"6b2b7746-fc66-5491-b896-e6261df254c9","stable_key":"import-1bbf9d44-8d2b-5b35-8f82-f6876558b0b3","title":"Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}