{"id":"ef472ef4-676f-51d4-bc67-6a3dad1cc949","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-quinone-formation","predicate":"oxidized_to","statement":"Myricetin oxidation to a quinone intermediate enabled the reported cell-free amination reaction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bf7deafc-68a6-52bf-8cce-8997c7751d83","mechanism_event_label":"Oxidation creates a more reactive form.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"834080ae-876c-5481-b4a3-d6bc8ad9fe95","slug":"myricetin-quinone","display_name":"Myricetin quinone, oxidation intermediate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"bf7deafc-68a6-52bf-8cce-8997c7751d83","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-quinone-formation-event","event_type":"observed_relationship","label":"Oxidation creates a more reactive form.","description":"Myricetin oxidation to a quinone intermediate enabled the reported cell-free amination reaction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"834080ae-876c-5481-b4a3-d6bc8ad9fe95","slug":"myricetin-quinone","display_name":"Myricetin quinone, oxidation intermediate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Chemical biotransformation experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An intermediate in this reaction is not a measured human circulating concentration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Oxidation creates a more reactive form.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31087612/ · DOI 10.1002/mnfr.201900203","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"848ff235-8196-504f-b887-8316fc8a418b","evidence_kind":"source_excerpt","locator":"Lines 52-58","start_line":52,"end_line":58,"excerpt":"## myricetin-quinone-formation\nOxidation creates a more reactive form.\nMyricetin oxidation to a quinone intermediate enabled the reported cell-free amination reaction.\nModel: Chemical biotransformation experiments.\nLimitations: An intermediate in this reaction is not a measured human circulating concentration.\nEvidence access: Primary abstract\nBiotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31087612/ · DOI 10.1002/mnfr.201900203","model_system":"Chemical biotransformation experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}