{"id":"eeebe428-befd-523a-b1d6-fdb9a3012d11","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-syt-knockout","predicate":"deletion_impairs","statement":"Synaptotagmin-1 knockout selectively impaired the fast component of both calcium- and strontium-induced neurotransmitter release in mouse neurons.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"767d5cb9-60d3-5046-afc1-c3f974f19376","mechanism_event_label":"Fast release needs this sensor even when strontium replaces calcium experimentally.","subject":{"id":"1751c77d-d58a-5dfa-9c27-8109cada64a6","slug":"mouse-syt1","display_name":"Mouse synaptotagmin 1 / Syt1","entity_type_key":"protein"},"object":{"id":"422240e0-86d7-5e12-a5af-ebbcad955ee9","slug":"mouse-strontium-fast-neurotransmitter-release","display_name":"Fast strontium-triggered release at mouse synapses","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"767d5cb9-60d3-5046-afc1-c3f974f19376","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-syt-knockout-event","event_type":"observed_relationship","label":"Fast release needs this sensor even when strontium replaces calcium experimentally.","description":"Synaptotagmin-1 knockout selectively impaired the fast component of both calcium- and strontium-induced neurotransmitter release in mouse neurons.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1751c77d-d58a-5dfa-9c27-8109cada64a6","slug":"mouse-syt1","display_name":"Mouse synaptotagmin 1 / Syt1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"422240e0-86d7-5e12-a5af-ebbcad955ee9","slug":"mouse-strontium-fast-neurotransmitter-release","display_name":"Fast strontium-triggered release at mouse synapses","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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