{"id":"eed8db1c-b98d-5774-8fba-b4608dd7dcdd","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-skin-med-null","predicate":"did_not_significantly_change","statement":"The visually assessed minimal erythema dose did not differ significantly between groups.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1546df01-85b0-5f77-89d7-9a512e85f331","mechanism_event_label":"A different redness endpoint did not show the same statistical result.","subject":{"id":"7ad842ec-c311-52bc-94de-8919c6e04bbc","slug":"tomato-paste-intervention","display_name":"Study-specific tomato paste food intervention","entity_type_key":"chemical_species"},"object":{"id":"285bddd3-7d1a-5cc6-ab96-6a485e6627f1","slug":"uv-minimal-erythema-dose","display_name":"Visually assessed UV minimal erythema dose","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1546df01-85b0-5f77-89d7-9a512e85f331","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-skin-med-null-event","event_type":"biochemical_relationship","label":"A different redness endpoint did not show the same statistical result.","description":"The visually assessed minimal erythema dose did not differ significantly between groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"food_component_not_isolated","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7ad842ec-c311-52bc-94de-8919c6e04bbc","slug":"tomato-paste-intervention","display_name":"Study-specific tomato paste food intervention","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"285bddd3-7d1a-5cc6-ab96-6a485e6627f1","slug":"uv-minimal-erythema-dose","display_name":"Visually assessed UV minimal erythema dose","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/20854436.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"70a295ef309afb9296521357fe29b70f532c2fd215687c918b94ee027aa707ba\", \"start_char\": 0, \"end_char\": 2063, \"text_sha256\": \"70a295ef309afb9296521357fe29b70f532c2fd215687c918b94ee027aa707ba\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized tomato-paste versus olive-oil trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"55 g tomato paste providing 16 mg lycopene daily in olive oil for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole food exposure; UV endpoints differ; not evidence that lycopene replaces sunscreen or prevents skin cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 20 women with skin phototypes I/II","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A different redness endpoint did not show the same statistical result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p20854436] Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/20854436/ DOI: 10.1111/j.1365-2133.2010.10057.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"UV-exposed skin and biopsies","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"01372b30-38a1-5103-8166-572d4fb83cba","evidence_kind":"source_excerpt","locator":"Lines 1196-1207","start_line":1196,"end_line":1207,"excerpt":"### lycopene-skin-med-null\nThe visually assessed minimal erythema dose did not differ significantly between groups.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A different redness endpoint did not show the same statistical result.\norganism: Human, 20 women with skin phototypes I/II\ntissue_or_cell_type: UV-exposed skin and biopsies\nexperimental_model: Randomized tomato-paste versus olive-oil trial\nlimitations: Whole food exposure; UV endpoints differ; not evidence that lycopene replaces sunscreen or prevents skin cancer.\nexposure: 55 g tomato paste providing 16 mg lycopene daily in olive oil for 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/20854436.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"70a295ef309afb9296521357fe29b70f532c2fd215687c918b94ee027aa707ba\", \"start_char\": 0, \"end_char\": 2063, \"text_sha256\": \"70a295ef309afb9296521357fe29b70f532c2fd215687c918b94ee027aa707ba\"}\n[lycopene-p20854436] Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/20854436/ DOI: 10.1111/j.1365-2133.2010.10057.x","model_system":"Randomized tomato-paste versus olive-oil trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lycopene-p20854436] Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. (2011). https://pubmed.ncbi.nlm.nih.gov/20854436/ DOI: 10.1111/j.1365-2133.2010.10057.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d1e09874-8bde-548f-9664-26ad5eedb3c7","stable_key":"import-aad5a443-96e9-52eb-963a-812e90f9f896","title":"Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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