{"id":"ee951945-5e67-50fd-ac22-9c31b7899e70","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-vitc-stability","predicate":"increases","statement":"Adding 30 mg ascorbic acid to 250 mL tea increased EGCG recovery after simulated digestion to 54%, versus at most 10% without protective formulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d0fa9cb5-4526-500e-8d99-994cccbe71b0","mechanism_event_label":"Vitamin C protected EGCG in a simulated digestive system.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"70707e0a-df45-5ce3-ba78-8da25f1cbff8","slug":"egcg-digestive-recovery","display_name":"EGCG recovery after simulated digestion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d0fa9cb5-4526-500e-8d99-994cccbe71b0","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-vitc-stability-event","event_type":"observed_relationship","label":"Vitamin C protected EGCG in a simulated digestive system.","description":"Adding 30 mg ascorbic acid to 250 mL tea increased EGCG recovery after simulated digestion to 54%, versus at most 10% without protective formulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"70707e0a-df45-5ce3-ba78-8da25f1cbff8","slug":"egcg-digestive-recovery","display_name":"EGCG recovery after simulated digestion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"In-vitro gastric/small-intestinal digestion with HPLC recovery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Recovery is chemical survival, not measured human absorption or clinical synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Vitamin C protected EGCG in a simulated digestive system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Common tea formulations modulate in vitro digestive recovery of green tea catechins. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17688297/ · DOI 10.1002/mnfr.200700086","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6d67640b-7e0e-543f-9814-b86aa45c80bd","evidence_kind":"source_excerpt","locator":"Lines 452-458","start_line":452,"end_line":458,"excerpt":"## egcg-vitc-stability\nVitamin C protected EGCG in a simulated digestive system.\nAdding 30 mg ascorbic acid to 250 mL tea increased EGCG recovery after simulated digestion to 54%, versus at most 10% without protective formulation.\nModel: In-vitro gastric/small-intestinal digestion with HPLC recovery.\nLimitations: Recovery is chemical survival, not measured human absorption or clinical synergy.\nEvidence access: primary abstract.\nCommon tea formulations modulate in vitro digestive recovery of green tea catechins. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17688297/ · DOI 10.1002/mnfr.200700086","model_system":"In-vitro gastric/small-intestinal digestion with HPLC recovery.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}