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topical membership is not evidence of a direct dietary effect.\nplain_language: Magnesium supports this NAD-linked folate reaction.\norganism: Rattus norvegicus\ntissue_or_cell_type: Cell-free\nexperimental_model: Cofactor omission/addition assays\nlimitations: No dietary magnesium threshold follows from these assays.\nexposure: Assay conditions described in the linked primary study.\ncross_nutrient: Direct magnesium/phosphate requirement in folate oxidation.\n[shin-2014] Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues (2014). https://pubmed.ncbi.nlm.nih.gov/24733394/ DOI: 10.1074/jbc.m114.555573","model_system":"Cofactor omission/addition assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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