{"id":"ee5fc835-2acf-52d1-9117-df9036d62056","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-sodium","predicate":"supports","statement":"Thiocyanate transport required basolateral sodium and concentrated thiocyanate tenfold apically.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"86cc6b74-253f-5035-be11-9ef6c7e325be","mechanism_event_label":"Sodium-dependent delivery supplies the airway defence system.","subject":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"object":{"id":"a1fbf329-dc04-5bed-b184-6c339c4cf72a","slug":"airway-thiocyanate-transport","display_name":"Transepithelial airway thiocyanate transport","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"86cc6b74-253f-5035-be11-9ef6c7e325be","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-air-sodium-event","event_type":"observed_relationship","label":"Sodium-dependent delivery supplies the airway defence system.","description":"Thiocyanate transport required basolateral sodium and concentrated thiocyanate tenfold apically.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a1fbf329-dc04-5bed-b184-6c339c4cf72a","slug":"airway-thiocyanate-transport","display_name":"Transepithelial airway thiocyanate transport","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d54e0a3-869f-5132-82c9-4c0ff47cd400","slug":"thiocyanate-ion","display_name":"Thiocyanate ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0d051c22-c0d2-5c22-91ad-4ee6894dc7a0","slug":"slc5a5","display_name":"Human sodium/iodide symporter / SLC5A5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed apical CFTR route was inferred pharmacologically, not proven by this experiment. This is iodide biology, not a KI-specific counter-ion effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Sodium-dependent delivery supplies the airway defence system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Transcellular thiocyanate transport by human airway epithelia. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15345749/ · DOI 10.1113/jphysiol.2004.071548","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0ae47500-47a1-50b7-8df9-34bc5ab4391c","evidence_kind":"source_excerpt","locator":"Lines 152-158","start_line":152,"end_line":158,"excerpt":"## ki-air-sodium\nSodium-dependent delivery supplies the airway defence system.\nThiocyanate transport required basolateral sodium and concentrated thiocyanate tenfold apically.\nModel: Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.\nLimitations: The proposed apical CFTR route was inferred pharmacologically, not proven by this experiment. This is iodide biology, not a KI-specific counter-ion effect.\nEvidence location: Primary abstract\nTranscellular thiocyanate transport by human airway epithelia. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15345749/ · DOI 10.1113/jphysiol.2004.071548","model_system":"Human airway epithelial cells at an air–liquid interface; transepithelial radiotracer transport.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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