{"id":"ee5f18f6-b64d-5735-8dcb-5aebceba93ab","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rat-cortical-firing","predicate":"reduces","statement":"Local indicaxanthin reduced cortical-neuron firing at the two higher tested amounts in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e19c1a47-b1a8-5584-b548-5668b13d7f70","mechanism_event_label":"Local indicaxanthin reduced cortical-neuron firing at the two higher tested amounts in rats.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"fcb4d68b-c5c8-59bb-80a6-b58a1c5ddc5f","slug":"rat-cortical-neuronal-firing","display_name":"Rat cortical neuronal firing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e19c1a47-b1a8-5584-b548-5668b13d7f70","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rat-cortical-firing-event","event_type":"observed_relationship","label":"Local indicaxanthin reduced cortical-neuron firing at the two higher tested amounts in rats.","description":"Local indicaxanthin reduced cortical-neuron firing at the two higher tested amounts in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fcb4d68b-c5c8-59bb-80a6-b58a1c5ddc5f","slug":"rat-cortical-neuronal-firing","display_name":"Rat cortical neuronal firing","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Indicaxanthin 0.085, 0.17 and 0.34 ng/neuron","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute recording; local application for 5 min","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; 2018 regional neuronal results additionally inspected in PMC full text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In vivo rat single-neuron recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Effects varied by region and dose. Direct striatal application produced effects even though oral-dose tissue analysis did not detect pigment there.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"In vivo rat single-neuron recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Local indicaxanthin reduced cortical-neuron firing at the two higher tested amounts in rats.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Brain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Opuntia Ficus Indica Administered at Nutritionally-Relevant Amounts. (2018). https://pubmed.ncbi.nlm.nih.gov/29867444/ DOI: 10.3389/fnagi.2018.00133","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Local microiontophoresis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cortex and striatum","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3379ad7a-8f6f-5e10-ab18-791fee93fbbf","evidence_kind":"source_excerpt","locator":"Lines 239-248","start_line":239,"end_line":248,"excerpt":"## indicaxanthin-rat-cortical-firing\nLocal indicaxanthin reduced cortical-neuron firing at the two higher tested amounts in rats.\nModel/species: In vivo rat single-neuron recordings\nTissue: Cortex and striatum\nExposure: Indicaxanthin 0.085, 0.17 and 0.34 ng/neuron\nRoute: Local microiontophoresis\nDuration: Acute recording; local application for 5 min\nLimits: Effects varied by region and dose. Direct striatal application produced effects even though oral-dose tissue analysis did not detect pigment there.\nPrimary reference: Brain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Opuntia Ficus Indica Administered at Nutritionally-Relevant Amounts. (2018). https://pubmed.ncbi.nlm.nih.gov/29867444/ DOI: 10.3389/fnagi.2018.00133\nAccess: Primary PubMed abstract; 2018 regional neuronal results additionally inspected in PMC full text.","model_system":"In vivo rat single-neuron recordings","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text.","file_path":"","sha256":"fd5e7b3a108073af5a8cad0e226a483ae2cda3b0e1daed387553ee441acecd5f","revision_id":"f3357c22-1be7-5502-b4f5-415d19c3cf5a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}