{"id":"ee49c064-0491-54ee-b2b8-2ba597e74bc0","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-oral-dose","predicate":"has_dose_dependent","statement":"Single oral L-carnitine doses had estimated bioavailability of 16% at 2 g and 5% at 6 g, with similar plasma exposure despite the higher dose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a95db949-a407-5d54-88d9-da8b9c12a956","mechanism_event_label":"A larger oral dose did not yield proportionally more circulating carnitine.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"de471f41-eb54-5474-a17e-1d903311df1b","slug":"human-carnitine-oral-bioavailability","display_name":"Human oral supplemental carnitine bioavailability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a95db949-a407-5d54-88d9-da8b9c12a956","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-oral-dose-event","event_type":"observed_relationship","label":"A larger oral dose did not yield proportionally more circulating carnitine.","description":"Single oral L-carnitine doses had estimated bioavailability of 16% at 2 g and 5% at 6 g, with similar plasma exposure despite the higher dose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"de471f41-eb54-5474-a17e-1d903311df1b","slug":"human-carnitine-oral-bioavailability","display_name":"Human oral supplemental carnitine bioavailability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six healthy adults on a low-carnitine diet; oral and IV comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Supplement boluses do not establish food bioavailability or tissue loading.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A larger oral dose did not yield proportionally more circulating carnitine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects. · 1988 · https://pubmed.ncbi.nlm.nih.gov/3220097/ · DOI 10.1007/BF00555510","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"289ef7f4-1c1c-5fce-ae83-0975a5a5fb0b","evidence_kind":"source_excerpt","locator":"Lines 34-40","start_line":34,"end_line":40,"excerpt":"## l-carnitine-oral-dose\nA larger oral dose did not yield proportionally more circulating carnitine.\nSingle oral L-carnitine doses had estimated bioavailability of 16% at 2 g and 5% at 6 g, with similar plasma exposure despite the higher dose.\nModel: Six healthy adults on a low-carnitine diet; oral and IV comparisons.\nLimitations: Supplement boluses do not establish food bioavailability or tissue loading.\nEvidence access: Primary abstract\nPharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects. · 1988 · https://pubmed.ncbi.nlm.nih.gov/3220097/ · DOI 10.1007/BF00555510","model_system":"Six healthy adults on a low-carnitine diet; oral and IV comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"6fcd86d9d02babb48b2ce658d506afe84580ad4b242f93f11f742d934fa5b361","revision_id":"398e3b52-45bc-52e3-891e-656c19ca674f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}