{"id":"ee2fc399-2a1c-58e6-bc4c-b4ed327663cd","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-folate-no-hcy-rescue-bhmt","predicate":"does_not_normalize","statement":"Feeding 20 mg folate/kg diet did not ameliorate elevated plasma homocysteine in Bhmt-null mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a9924720-f427-5a16-b432-1f39cb1b86ee","mechanism_event_label":"Extra folate did not restore this missing route.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a9924720-f427-5a16-b432-1f39cb1b86ee","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-folate-no-hcy-rescue-bhmt-event","event_type":"biochemical_relationship","label":"Extra folate did not restore this missing route.","description":"Feeding 20 mg folate/kg diet did not ameliorate elevated plasma homocysteine in Bhmt-null mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e6946c3a-4f7f-53b5-b813-762a6c5bf94c","slug":"bhmt-mouse-gene","display_name":"Bhmt gene (Mus musculus)","entity_type_key":"gene"},"role":"deleted gene","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2ed20a5-c46b-5d60-9368-35d4969b6980","slug":"betaine","display_name":"Betaine","entity_type_key":"small_molecule"},"role":"BHMT methyl donor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [teng-2012] Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake (2012). https://pubmed.ncbi.nlm.nih.gov/23014492/ DOI: 10.3945/jn.112.166835","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}