{"id":"ee2c3c68-8bf9-52b4-96b3-73859b0b03dc","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-chromophore","predicate":"stabilizes","statement":"Bovine rhodopsin crystallography identifies 11-cis-retinal within the inactive seven-helix receptor.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8393c26a-0e84-5004-b619-3af2c4a88ca1","mechanism_event_label":"The cis retinal isomer is the rod pigment chromophore.","subject":{"id":"2df0d238-71af-5f0b-8359-cef18235c4af","slug":"11-cis-retinal","display_name":"11-cis-retinal","entity_type_key":"small_molecule"},"object":{"id":"22f904b7-271d-5a7b-963c-580663bd37ab","slug":"rhodopsin","display_name":"Rhodopsin","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"8393c26a-0e84-5004-b619-3af2c4a88ca1","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-chromophore-event","event_type":"biochemical_relationship","label":"The cis retinal isomer is the rod pigment chromophore.","description":"Bovine rhodopsin crystallography identifies 11-cis-retinal within the inactive seven-helix receptor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b846a695-4ca7-5df7-b13e-56922410ff94","slug":"rho","display_name":"Rod opsin / RHO","entity_type_key":"protein"},"role":"protein component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2df0d238-71af-5f0b-8359-cef18235c4af","slug":"11-cis-retinal","display_name":"11-cis-retinal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22f904b7-271d-5a7b-963c-580663bd37ab","slug":"rhodopsin","display_name":"Rhodopsin","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"2.8-angstrom crystal structure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A static ground-state structure does not measure dietary requirements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Bos taurus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cis retinal isomer is the rod pigment chromophore.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[palczewski-2000] Crystal structure of rhodopsin: A G protein-coupled receptor (2000). https://pubmed.ncbi.nlm.nih.gov/10926528/ DOI: 10.1126/science.289.5480.739","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Rod photopigment","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4f2ec764-dde3-5913-8b9c-411c7224ade8","evidence_kind":"source_excerpt","locator":"Lines 644-653","start_line":644,"end_line":653,"excerpt":"### a-vision-chromophore\nBovine rhodopsin crystallography identifies 11-cis-retinal within the inactive seven-helix receptor.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The cis retinal isomer is the rod pigment chromophore.\norganism: Bos taurus\ntissue_or_cell_type: Rod photopigment\nexperimental_model: 2.8-angstrom crystal structure\nlimitations: A static ground-state structure does not measure dietary requirements.\n[palczewski-2000] Crystal structure of rhodopsin: A G protein-coupled receptor (2000). https://pubmed.ncbi.nlm.nih.gov/10926528/ DOI: 10.1126/science.289.5480.739","model_system":"2.8-angstrom crystal structure","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [palczewski-2000] Crystal structure of rhodopsin: A G protein-coupled receptor (2000). https://pubmed.ncbi.nlm.nih.gov/10926528/ DOI: 10.1126/science.289.5480.739","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}