{"id":"edc13ae9-1677-5a9d-aa12-6f6f7a905aed","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-calcium-recovery-precedes-calcitriol","predicate":"repletion_changes","statement":"Magnesium treatment normalized mean serum calcium, while calcitriol rose into or above normal in only five of the 23 patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ca0f3805-76f9-598d-9ea4-99bb48828bab","mechanism_event_label":"Restoring magnesium did not automatically normalize every vitamin D result.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ca0f3805-76f9-598d-9ea4-99bb48828bab","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-calcium-recovery-precedes-calcitriol-event","event_type":"observed_intervention","label":"Restoring magnesium did not automatically normalize every vitamin D result.","description":"Magnesium treatment normalized mean serum calcium, while calcitriol rose into or above normal in only five of the 23 patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"incompletely_restored_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"measured_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Magnesium -> calcium response; vitamin D normalization is not obligatory in this cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Five to thirteen days of parenteral Mg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nonrandomized clinical response; calcium recovery does not prove that calcitriol rose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Restoring magnesium did not automatically normalize every vitamin D result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-rude1985] Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency (1985). https://pubmed.ncbi.nlm.nih.gov/3840173/ DOI: 10.1210/jcem-61-5-933","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human serum; circulating mineral and vitamin D metabolites","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e78bffec-d0f4-527e-98cd-a54a33a51e72","evidence_kind":"source_excerpt","locator":"Lines 1358-1368","start_line":1358,"end_line":1368,"excerpt":"### mg-calcium-recovery-precedes-calcitriol\nMagnesium treatment normalized mean serum calcium, while calcitriol rose into or above normal in only five of the 23 patients.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Restoring magnesium did not automatically normalize every vitamin D result.\norganism: Homo sapiens\ntissue_or_cell_type: Human serum; circulating mineral and vitamin D metabolites\nexperimental_model: Five to thirteen days of parenteral Mg.\nlimitations: Nonrandomized clinical response; calcium recovery does not prove that calcitriol rose.\ncross_nutrient: Magnesium -> calcium response; vitamin D normalization is not obligatory in this cohort.\n[mg-rude1985] Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency (1985). https://pubmed.ncbi.nlm.nih.gov/3840173/ DOI: 10.1210/jcem-61-5-933","model_system":"Five to thirteen days of parenteral Mg.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mg-rude1985] Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency (1985). https://pubmed.ncbi.nlm.nih.gov/3840173/ DOI: 10.1210/jcem-61-5-933","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}