{"id":"edb9071a-d10e-57ce-be75-68a523f65990","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-human-meal-k-excretion-without-serum-rise","predicate":"meal-delivery-associated-with","statement":"A potassium-containing meal increased K excretion without a detected serum K rise in the human study; the response persisted with eplerenone.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"79d1320f-71e9-5132-ab72-b7d465c9f06e","mechanism_event_label":"People can increase potassium excretion after a meal before a measurable blood rise.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"7f78edef-2ff6-5c96-b8ff-dc3f48fb80cd","slug":"urinary-potassium-excretion","display_name":"Urinary potassium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"79d1320f-71e9-5132-ab72-b7d465c9f06e","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-human-meal-k-excretion-without-serum-rise-event","event_type":"observed_intervention","label":"People can increase potassium excretion after a meal before a measurable blood rise.","description":"A potassium-containing meal increased K excretion without a detected serum K rise in the human study; 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the response persisted with eplerenone.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: People can increase potassium excretion after a meal before a measurable blood rise.\norganism: Homo sapiens\ntissue_or_cell_type: Gastrointestinal-renal axis\nexperimental_model: Controlled meal challenges and MR-blockade comparison; 32 participants\nlimitations: Low-sodium controlled background; no gut receptor identified and complete aldosterone independence is an inference.\nevidence_location: Primary abstract; meal-plus-K and eplerenone comparisons.\n[preston-2015-gut-human] Evidence for a gastrointestinal-renal kaliuretic signaling axis in humans (2015). https://pubmed.ncbi.nlm.nih.gov/26308672/ DOI: 10.1038/ki.2015.243","model_system":"Controlled meal challenges and MR-blockade comparison; 32 participants","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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