{"id":"ed894245-baec-5692-af37-40dc21573146","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-depletion-recovery","predicate":"restores","statement":"Participants who developed organ dysfunction recovered normal organ function after incremental choline repletion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2c60c83b-8815-5083-8df8-a3468c61c6a1","mechanism_event_label":"The experimentally induced signs were reversible with choline restoration.","subject":{"id":"4323cb6f-582b-5ef9-9416-d4741728a69b","slug":"choline-repletion-diet","display_name":"Graded choline repletion after experimental human depletion","entity_type_key":"chemical_species"},"object":{"id":"012842ff-ca10-5e98-938a-1630d19fbcd3","slug":"human-choline-repletion-organ-recovery","display_name":"Organ-function recovery after controlled choline repletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2c60c83b-8815-5083-8df8-a3468c61c6a1","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-depletion-recovery-event","event_type":"observed_intervention","label":"The experimentally induced signs were reversible with choline restoration.","description":"Participants who developed organ dysfunction recovered normal organ function after incremental choline repletion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"role":"repleted_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4323cb6f-582b-5ef9-9416-d4741728a69b","slug":"choline-repletion-diet","display_name":"Graded choline repletion after experimental human depletion","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"012842ff-ca10-5e98-938a-1630d19fbcd3","slug":"human-choline-repletion-organ-recovery","display_name":"Organ-function recovery after controlled choline repletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/17490963.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\", \"start_char\": 0, \"end_char\": 1758, \"text_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled depletion/repletion with randomized folic acid supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"550 mg choline/70 kg/day for 10 days, then less than 50 mg/70 kg/day up to 42 days; graded repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Supervised experimental depletion, not a recommended intake protocol. 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Liver/muscle endpoints and susceptibility differed; one cohort underlies related genetic publications.\nexposure: 550 mg choline/70 kg/day for 10 days, then less than 50 mg/70 kg/day up to 42 days; graded repletion\nevidence_span: {\"source_cache\": \"artifacts/choline-research/17490963.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\", \"start_char\": 0, \"end_char\": 1758, \"text_sha256\": \"28d18f06c2deb6f384ef2b5e84238b05deb076778619c21ee9682d49e34ae824\"}\n[choline-p17490963] Sex and menopausal status influence human dietary requirements for the nutrient choline. 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