{"id":"ed623238-b325-5c3c-9222-162ee1c46f58","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:dpn05-conduction-null","predicate":"no_detected_change_in_recorded_comparison","statement":"Nerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"62aa871e-222f-58b6-95fc-3235123eb14e","mechanism_event_label":"Nerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.","subject":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"object":{"id":"f72e660a-b5e5-5240-aeaf-eea87bd76131","slug":"human-dpn-conduction","display_name":"Human diabetic-neuropathy nerve conduction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"62aa871e-222f-58b6-95fc-3235123eb14e","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:dpn05-conduction-null-event","event_type":"experimental_observation","label":"Nerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.","description":"### dpn05-conduction-null\n\nNerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.\nNegative electrophysiology is retained alongside favorable vibration and morphometry.\nModel and exposure: Two 52-week placebo-controlled trials; 1,257 ITT patients; 500 or 1,000 mg three times daily.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. | 2005 | https://pubmed.ncbi.nlm.nih.gov/15616239/ | https://doi.org/10.2337/diacare.28.1.89 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"ALCAR regimen","sequence_order":0,"notes":""},{"entity":{"id":"f72e660a-b5e5-5240-aeaf-eea87bd76131","slug":"human-dpn-conduction","display_name":"Human diabetic-neuropathy nerve conduction","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"ALCAR regimen\", \"comparator\": \"Placebo\", \"endpoint\": \"Nerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Two 52-week placebo-controlled trials; 1,257 ITT patients; 500 or 1,000 mg three times daily.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived curation with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Nerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. | https://pubmed.ncbi.nlm.nih.gov/15616239/ | https://doi.org/10.2337/diacare.28.1.89","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference dpn05-conduction-null; Negative electrophysiology is retained alongside favorable vibration and morphometry.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cf93ce55-8a4d-547c-90ce-ef1a063dca8e","evidence_kind":"source_excerpt","locator":"Lines 491-497","start_line":491,"end_line":497,"excerpt":"### dpn05-conduction-null\n\nNerve-conduction velocities and amplitudes did not improve in the pooled 2005 ALCAR trial analysis.\nNegative electrophysiology is retained alongside favorable vibration and morphometry.\nModel and exposure: Two 52-week placebo-controlled trials; 1,257 ITT patients; 500 or 1,000 mg three times daily.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. | 2005 | https://pubmed.ncbi.nlm.nih.gov/15616239/ | https://doi.org/10.2337/diacare.28.1.89 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Two 52-week placebo-controlled trials; 1,257 ITT patients; 500 or 1,000 mg three times daily.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2588f904-245a-597a-8a12-65118013fb90","stable_key":"import-e3f6ce02-0bd7-5103-acc1-68503ab6751b","title":"Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed.","file_path":"","sha256":"84cc82d6fbb0fd5d73c4ce779e9f88e7f0184ba2d29b18ad0f153815380f2975","revision_id":"dac7a950-dbe5-5c7a-9c70-2ea711d5c71a","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}