{"id":"ed2f1037-486e-5596-a33a-39e41ef1a912","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-estradiol","predicate":"reduces_within_group","statement":"The 6 g/day D-aspartate arm showed a reported 16% estradiol decrease over 12 weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"737b6233-44ab-59b1-abc5-3f84525a8856","mechanism_event_label":"One trial measured an estrogen change alongside unchanged testosterone.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"2a6f9e7b-63b9-5afc-bef0-5d5f9699c2a4","slug":"human-dasp-trial-estradiol","display_name":"Estradiol in the 12-week D-aspartate trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"737b6233-44ab-59b1-abc5-3f84525a8856","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-estradiol-event","event_type":"observed_relationship","label":"One trial measured an estrogen change alongside unchanged testosterone.","description":"The 6 g/day D-aspartate arm showed a reported 16% estradiol decrease over 12 weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a6f9e7b-63b9-5afc-bef0-5d5f9699c2a4","slug":"human-dasp-trial-estradiol","display_name":"Estradiol in the 12-week D-aspartate trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Resistance-trained men; within-group change estimate, 95% confidence interval -27% to -5%.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not prove direct aromatase inhibition or establish a hormone-management treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One trial measured an estrogen change alongside unchanged testosterone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28841667/ · DOI 10.1371/journal.pone.0182630","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ca1bb661-aa0a-5c2b-8731-769462033fe2","evidence_kind":"source_excerpt","locator":"Lines 360-366","start_line":360,"end_line":366,"excerpt":"## d-aspartate-human-estradiol\nOne trial measured an estrogen change alongside unchanged testosterone.\nThe 6 g/day D-aspartate arm showed a reported 16% estradiol decrease over 12 weeks.\nModel: Resistance-trained men; within-group change estimate, 95% confidence interval -27% to -5%.\nLimitations: This does not prove direct aromatase inhibition or establish a hormone-management treatment.\nEvidence access: Primary full text\nThe effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28841667/ · DOI 10.1371/journal.pone.0182630","model_system":"Resistance-trained men; within-group change estimate, 95% confidence interval -27% to -5%.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0a86a1008edb8a69dcc79409e76e3fd5ce59b0747be8cae8f21e43f871e76248","revision_id":"a1de4b66-263d-5452-8ed8-df853afba030","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}