{"id":"ec24d588-9b63-5ed4-bbf7-fa176cc0ff92","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-lacphe-exercise","predicate":"increases_after","statement":"Lac-Phe rose after exercise in human cohorts of 36 and 8 participants; in the modality comparison, changes tracked lactate and were greatest after sprint exercise.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d61dd0e5-ecde-5239-a55b-e7d6f685a66c","mechanism_event_label":"Phenylalanine can join lactate in a metabolite that rises after exercise.","subject":{"id":"2e1e9f48-df5d-5d8a-a1e9-96e90a6eb6d1","slug":"n-lactoyl-phenylalanine","display_name":"N-Lactoyl-phenylalanine / Lac-Phe","entity_type_key":"small_molecule"},"object":{"id":"df5d5168-a576-5be5-a638-ff1da1e6f89a","slug":"human-exercise-lacphe","display_name":"Human exercise-associated circulating Lac-Phe","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d61dd0e5-ecde-5239-a55b-e7d6f685a66c","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-lacphe-exercise-event","event_type":"observed_relationship","label":"Phenylalanine can join lactate in a metabolite that rises after exercise.","description":"Lac-Phe rose after exercise in human cohorts of 36 and 8 participants; in the modality comparison, changes tracked lactate and were greatest after sprint exercise.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2e1e9f48-df5d-5d8a-a1e9-96e90a6eb6d1","slug":"n-lactoyl-phenylalanine","display_name":"N-Lactoyl-phenylalanine / Lac-Phe","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"df5d5168-a576-5be5-a638-ff1da1e6f89a","slug":"human-exercise-lacphe","display_name":"Human exercise-associated circulating Lac-Phe","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5ebd9a7c-b151-5b70-b70d-7d33067d4ebf","slug":"lactate","display_name":"L-Lactate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"66621280-d7e5-5e8b-8ae1-873711628d87","slug":"human-cndp2","display_name":"Human cytosolic nonspecific dipeptidase / CNDP2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human metabolomics and endurance/sprint/resistance comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A biomarker rise is not evidence that taking phenylalanine reproduces exercise benefits.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Phenylalanine can join lactate in a metabolite that rises after exercise.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"An exercise-inducible metabolite that suppresses feeding and obesity. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35705806/ · DOI 10.1038/s41586-022-04828-5","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d30cdee9-5a74-55c9-812c-123e42c688b6","evidence_kind":"source_excerpt","locator":"Lines 398-404","start_line":398,"end_line":404,"excerpt":"## l-phenylalanine-lacphe-exercise\nPhenylalanine can join lactate in a metabolite that rises after exercise.\nLac-Phe rose after exercise in human cohorts of 36 and 8 participants; in the modality comparison, changes tracked lactate and were greatest after sprint exercise.\nModel: Human metabolomics and endurance/sprint/resistance comparisons.\nLimitations: A biomarker rise is not evidence that taking phenylalanine reproduces exercise benefits.\nEvidence access: Primary full text\nAn exercise-inducible metabolite that suppresses feeding and obesity. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35705806/ · DOI 10.1038/s41586-022-04828-5","model_system":"Human metabolomics and endurance/sprint/resistance comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54de7c56-1e60-5d7b-8ef9-852c58ae92ba","stable_key":"import-56f1d914-e7da-595a-af69-c217b2b47407","title":"L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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