{"id":"ec058c93-a04b-52b8-910a-524fd1823f1d","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mouse-nrf2","predicate":"increases_expression","statement":"Myricetin increased hepatic Nrf2 expression in mice challenged with LPS/D-galactosamine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"aa1e4daa-1a80-5b5d-8adf-09484e771052","mechanism_event_label":"A defense regulator increased in this liver-injury model.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"aa1e4daa-1a80-5b5d-8adf-09484e771052","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mouse-nrf2-event","event_type":"observed_relationship","label":"A defense regulator increased in this liver-injury model.","description":"Myricetin increased hepatic Nrf2 expression in mice challenged with LPS/D-galactosamine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse chemically induced fulminant hepatitis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not universal Nrf2 activation or evidence of clinical hepatoprotection. The abstract calls myricetin a glycoside; this collection retains its correct aglycone identity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A defense regulator increased in this liver-injury model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31712142/ · DOI 10.1016/j.ijbiomac.2019.11.075","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"23122710-8c48-565d-83ee-2322d044a12e","evidence_kind":"source_excerpt","locator":"Lines 636-642","start_line":636,"end_line":642,"excerpt":"## myricetin-mouse-nrf2\nA defense regulator increased in this liver-injury model.\nMyricetin increased hepatic Nrf2 expression in mice challenged with LPS/D-galactosamine.\nModel: Mouse chemically induced fulminant hepatitis.\nLimitations: Not universal Nrf2 activation or evidence of clinical hepatoprotection. The abstract calls myricetin a glycoside; this collection retains its correct aglycone identity.\nEvidence access: Primary abstract\nThe hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31712142/ · DOI 10.1016/j.ijbiomac.2019.11.075","model_system":"Mouse chemically induced fulminant hepatitis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}