{"id":"ebb112b8-a075-5e38-a41e-34e0ce3430c8","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-microbial-dehydroxylation","predicate":"is_converted_to","statement":"Human fecal fermentation and urine analyses identified 3,4′-Dihydroxy-trans-stilbene among trans-resveratrol-derived microbial metabolites.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d7005bb5-df9b-540a-8c6a-5b9e60d2feed","mechanism_event_label":"Gut microbes change which molecules reach the body.","subject":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"e33d27d8-6dae-59b8-8cb2-33bd50e5bc75","slug":"3-4-prime-dihydroxystilbene","display_name":"3,4′-Dihydroxy-trans-stilbene","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d7005bb5-df9b-540a-8c6a-5b9e60d2feed","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-microbial-dehydroxylation-event","event_type":"observed_relationship","label":"Gut microbes change which molecules reach the body.","description":"Human fecal fermentation and urine analyses identified 3,4′-Dihydroxy-trans-stilbene among trans-resveratrol-derived microbial metabolites.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e33d27d8-6dae-59b8-8cb2-33bd50e5bc75","slug":"3-4-prime-dihydroxystilbene","display_name":"3,4′-Dihydroxy-trans-stilbene","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Seven fecal donors; separate 12-person intervention using grapevine-shoot supplement at 0.5 mg/kg.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Metabolite patterns varied by person; a mixed supplement is not a purified-compound clinical efficacy test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Gut microbes change which molecules reach the body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23283496/ · DOI 10.3945/ajcn.112.049379","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34870ce4-8896-5d94-af54-4a979d5e1100","evidence_kind":"source_excerpt","locator":"Lines 62-68","start_line":62,"end_line":68,"excerpt":"## resveratrol-microbial-dehydroxylation\nGut microbes change which molecules reach the body.\nHuman fecal fermentation and urine analyses identified 3,4′-Dihydroxy-trans-stilbene among trans-resveratrol-derived microbial metabolites.\nModel: Seven fecal donors; separate 12-person intervention using grapevine-shoot supplement at 0.5 mg/kg.\nLimitations: Metabolite patterns varied by person; a mixed supplement is not a purified-compound clinical efficacy test.\nEvidence access: Primary abstract\nIn vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23283496/ · DOI 10.3945/ajcn.112.049379","model_system":"Seven fecal donors; separate 12-person intervention using grapevine-shoot supplement at 0.5 mg/kg.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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