{"id":"eb5c0acf-cbb6-5b78-91e1-d42b2a7ad090","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-microsome-oxidation","predicate":"inhibits","statement":"Astaxanthin inhibited radical-induced lipid peroxidation in rat liver microsomes, with activity comparable to alpha-tocopherol under the tested conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dd32dc2b-d049-596a-8944-7d3af3f71476","mechanism_event_label":"It interrupted oxidation in an experimental membrane preparation.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dd32dc2b-d049-596a-8944-7d3af3f71476","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-microsome-oxidation-event","event_type":"observed_relationship","label":"It interrupted oxidation in an experimental membrane preparation.","description":"Astaxanthin inhibited radical-induced lipid peroxidation in rat liver microsomes, with activity comparable to alpha-tocopherol under the tested conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat liver microsomal oxidation assay under air.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not support a universal potency multiplier over vitamin E or human clinical efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"It interrupted oxidation in an experimental membrane preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin and canthaxanthin are potent antioxidants in a membrane model. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1497349/ · DOI 10.1016/0003-9861(92)90675-m","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b0bf73f4-4826-5d54-9183-f7ad60a4edae","evidence_kind":"source_excerpt","locator":"Lines 150-156","start_line":150,"end_line":156,"excerpt":"## astaxanthin-microsome-oxidation\nIt interrupted oxidation in an experimental membrane preparation.\nAstaxanthin inhibited radical-induced lipid peroxidation in rat liver microsomes, with activity comparable to alpha-tocopherol under the tested conditions.\nModel: Rat liver microsomal oxidation assay under air.\nLimitations: This does not support a universal potency multiplier over vitamin E or human clinical efficacy.\nEvidence access: Primary abstract\nAstaxanthin and canthaxanthin are potent antioxidants in a membrane model. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1497349/ · DOI 10.1016/0003-9861(92)90675-m","model_system":"Rat liver microsomal oxidation assay under air.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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