{"id":"eb479176-7b33-55cd-a91e-e8018e089b37","stable_key":"research:neural-selenoi-loss-increases-lipid-peroxidation","predicate":"loss-increases","statement":"Neural Selenoi deletion increased lipid-peroxidation readouts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"positive","is_public":true,"mechanism_event_id":"4b16cdd9-8a5a-55d5-9c52-f27dfde471cf","mechanism_event_label":"Loss of SELENOI increased lipid damage in this neural model.","subject":{"id":"8334e065-581a-5500-b664-dbe129850043","slug":"selenoi","display_name":"SELENOI","entity_type_key":"protein"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4b16cdd9-8a5a-55d5-9c52-f27dfde471cf","stable_key":"research:neural-selenoi-loss-increases-lipid-peroxidation","event_type":"genetic-perturbation","label":"Loss of SELENOI increased lipid damage in this neural model.","description":"Neural Selenoi deletion increased lipid-peroxidation readouts.","status":"active","compartment":{"slug":"nervous-system","display_name":"Nervous system"},"participants":[{"entity":{"id":"8334e065-581a-5500-b664-dbe129850043","slug":"selenoi","display_name":"SELENOI","entity_type_key":"protein"},"role":"perturbed-protein","stoichiometry":null,"state_label":"deleted","sequence_order":0,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"measured-process","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"neural lineage","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Indirect redox consequence does not establish SELENOI peroxidase activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"mouse","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8320bc85-814f-513f-84d2-8727c57f8713","evidence_kind":"curated_literature_summary","locator":"lines 774-784","start_line":774,"end_line":784,"excerpt":"## neural-selenoi-loss-increases-lipid-peroxidation\n\nLoss of SELENOI increased lipid damage in this neural model.\n\nNeural Selenoi deletion increased lipid-peroxidation readouts.\n\nOrganism: mouse\nCell type: neural lineage\nExperimental model: Conditional knockout\nLimitations: Indirect redox consequence does not establish SELENOI peroxidase activity.\nPrimary reference: [Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination](https://pubmed.ncbi.nlm.nih.gov/38582453/)","model_system":"Conditional knockout","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"neural-lipid-homeostasis","plain_language":"Loss of SELENOI increased lipid damage in this neural model.","evidence_scope":"direct_experimental","papers":[{"key":"nunes-2024-selenoi-myelin","title":"Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination","url":"https://pubmed.ncbi.nlm.nih.gov/38582453/","doi":"10.1016/j.jbc.2024.107259","year":2024,"model":"Neural-lineage Selenoi knockout mice","summary":"Links disturbed ether-lipid balance to impaired myelination and increased lipid peroxidation; Sec function remains unsettled."}]}}