{"id":"eaf4603b-588a-54ff-b0bb-b002f97043d7","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:metabolism-modafinil-acid","predicate":"reported_relationship","statement":"Modafinil metabolism includes hydrolytic deamidation to modafinil acid. Major-metabolite formation does not establish those metabolites as the source of central arousal.","claim_class":"mechanistic","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ce5504a2-bcce-50e4-8200-0c0266df6901","mechanism_event_label":"Modafinil metabolism includes hydrolytic deamidation to modafinil acid. Major-metabolite formation does not establish those metabolites as the source of central arousal.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"933d2261-f2be-565d-9005-57f92782b7e5","slug":"modafinil-acid","display_name":"Modafinil acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ce5504a2-bcce-50e4-8200-0c0266df6901","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:metabolism-modafinil-acid-event","event_type":"biochemical_relationship","label":"Modafinil metabolism includes hydrolytic deamidation to modafinil acid. Major-metabolite formation does not establish those metabolites as the source of central arousal.","description":"Food can delay peak concentration by about an hour without reducing overall exposure. Metabolism includes hydrolytic deamidation to modafinil acid and S-oxidation to modafinil sulfone; these major metabolites do not appear to explain central arousal. CYP involvement in metabolism and effects on other drugs' CYP-mediated clearance are separate questions. [Official pharmacokinetics](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b8d1c32-dac9-50e6-e063-6394a90aa5a5)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"933d2261-f2be-565d-9005-57f92782b7e5","slug":"modafinil-acid","display_name":"Modafinil acid","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Official label description, pharmacology, pharmacokinetics, indications, interactions and relevant warnings checked.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Product-label human pharmacokinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Modafinil metabolism includes hydrolytic deamidation to modafinil acid. Major-metabolite formation does not establish those metabolites as the source of central arousal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"PROVIGIL U.S. prescribing information | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b8d1c32-dac9-50e6-e063-6394a90aa5a5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 21-21; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"884d7145-262f-5c80-bf66-63c716afd828","evidence_kind":"source_excerpt","locator":"Lines 21-21","start_line":21,"end_line":21,"excerpt":"Food can delay peak concentration by about an hour without reducing overall exposure. Metabolism includes hydrolytic deamidation to modafinil acid and S-oxidation to modafinil sulfone; these major metabolites do not appear to explain central arousal. CYP involvement in metabolism and effects on other drugs' CYP-mediated clearance are separate questions. [Official pharmacokinetics](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b8d1c32-dac9-50e6-e063-6394a90aa5a5)","model_system":"Product-label human pharmacokinetics.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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