{"id":"ead8a592-fe20-586d-9d56-081c572dbafa","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-activates-p38","predicate":"activates","statement":"(+)-Lariciresinol activated p38 in murine macrophages.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"73b1319a-f21c-5de4-9f47-ad7156e3a7c2","mechanism_event_label":"(+)-Lariciresinol activated p38 in murine macrophages.","subject":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"object":{"id":"8e62ed16-0010-5b56-acf2-f0684433098d","slug":"p38-mapk","display_name":"p38 mitogen-activated protein kinase family","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"73b1319a-f21c-5de4-9f47-ad7156e3a7c2","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-activates-p38-event","event_type":"observed_relationship","label":"(+)-Lariciresinol activated p38 in murine macrophages.","description":"(+)-Lariciresinol activated p38 in murine macrophages.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e62ed16-0010-5b56-acf2-f0684433098d","slug":"p38-mapk","display_name":"p38 mitogen-activated protein kinase family","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"(+)-Lariciresinol isolated from Rubia philippinensis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract states p38 activation without giving concentrations or timing; those appear only in the full text and figures and were not read here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"(+)-Lariciresinol activated p38 in murine macrophages.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. (2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Mitogen-activated protein kinase phosphorylation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"28b57012-3826-55ee-9383-44ce3573da11","evidence_kind":"source_excerpt","locator":"Lines 11-20","start_line":11,"end_line":20,"excerpt":"## plus-lariciresinol-activates-p38\n(+)-Lariciresinol activated p38 in murine macrophages.\nModel/species: RAW 264.7 murine macrophages\nTissue/system: Mitogen-activated protein kinase phosphorylation\nExposure: (+)-Lariciresinol isolated from Rubia philippinensis\nRoute: In vitro\nDuration: Acute\nLimits: The abstract states p38 activation without giving concentrations or timing; those appear only in the full text and figures and were not read here.\nPrimary reference: Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. (2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. 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