{"id":"eac00c2d-69cf-5b5e-96d7-0ef6fbf138da","stable_key":"availability:selenoprotein-biomarker-plateaus:2","predicate":"has_saturable_activity_relationship_with","statement":"GPX3 activity can plateau as selenium supply increases, making it less informative near that plateau.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Human intervention for biomarker plateaus; supplied-source interpretation of measurement limits.","direction":"context_dependent","is_public":true,"mechanism_event_id":"b1bb91d7-6db1-563f-b618-a94a9121cdd1","mechanism_event_label":"GPX3 activity can plateau as selenium supply increases, making it less informative near that plateau.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"32f7aa34-135f-5bfb-9189-81634ad4a824","slug":"gpx3","display_name":"GPX3","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b1bb91d7-6db1-563f-b618-a94a9121cdd1","stable_key":"availability:selenoprotein-biomarker-plateaus:2","event_type":"availability_dependent_change","label":"GPX3 activity can plateau as selenium supply increases, making it less informative near that plateau.","description":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context. Human intervention dose-response observations and biomarker interpretation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"condition_input","stoichiometry":null,"state_label":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context.","sequence_order":0,"notes":""},{"entity":{"id":"32f7aa34-135f-5bfb-9189-81634ad4a824","slug":"gpx3","display_name":"GPX3","entity_type_key":"protein"},"role":"affected_component","stoichiometry":null,"state_label":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Human intervention dose-response observations and biomarker interpretation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study-specific plateaus cannot be mapped to GPX1 NMD, thyroid or immune failure, GPX4 loss, or an absolute antioxidant-to-pro-oxidant switch. Plasma and whole-blood values are not interchangeable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"05b40e04-d8bc-5d1e-b46f-aee8ed039e50","evidence_kind":"source_passage","locator":"lines 577-583","start_line":577,"end_line":583,"excerpt":"GPX3 activity\n\nSelenium-responsive and can plateau\n\nFunctional extracellular GPX activity\n\nBecomes less informative once activity is near plateau","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}