{"id":"eaae54f5-df8c-520e-ba0e-f4b724f97bc3","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-vascular-endothelial-release","predicate":"supports_local_release_of","statement":"Acetylcholine produced a local potassium rise and hyperpolarization sensitive to combined calcium-activated potassium-channel blockers in rat arteries.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5eb6147f-88f2-5c03-b234-8530f70f2b69","mechanism_event_label":"Potassium can act locally as a signal between vessel cells.","subject":{"id":"1706aa6f-28b1-58b0-b070-407b8359f916","slug":"vascular-calcium-activated-potassium-channels","display_name":"Vascular calcium-activated potassium channels","entity_type_key":"protein_family"},"object":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"5eb6147f-88f2-5c03-b234-8530f70f2b69","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-vascular-endothelial-release-event","event_type":"biochemical_relationship","label":"Potassium can act locally as a signal between vessel cells.","description":"Acetylcholine produced a local potassium rise and hyperpolarization sensitive to combined calcium-activated potassium-channel blockers in rat arteries.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"channel_regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1706aa6f-28b1-58b0-b070-407b8359f916","slug":"vascular-calcium-activated-potassium-channels","display_name":"Vascular calcium-activated potassium channels","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Calcium-regulated channel activity -> local potassium signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat isolated arteries; potassium electrodes and blockers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pharmacology does not uniquely identify an SK/IK gene; not a dietary intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Potassium can act locally as a signal between vessel cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Arterial endothelium and myoendothelial space","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"09844272-614d-56dd-ba37-826745cddfcc","evidence_kind":"source_excerpt","locator":"Lines 1580-1590","start_line":1580,"end_line":1590,"excerpt":"### k-vascular-endothelial-release\nAcetylcholine produced a local potassium rise and hyperpolarization sensitive to combined calcium-activated potassium-channel blockers in rat arteries.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Potassium can act locally as a signal between vessel cells.\norganism: Rattus norvegicus\ntissue_or_cell_type: Arterial endothelium and myoendothelial space\nexperimental_model: Rat isolated arteries; potassium electrodes and blockers.\nlimitations: Pharmacology does not uniquely identify an SK/IK gene; not a dietary intervention.\ncross_nutrient: Calcium-regulated channel activity -> local potassium signal.\n[k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388","model_system":"Rat isolated arteries; potassium electrodes and blockers.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}