{"id":"eaa21d99-ea70-5085-944e-f26b2c115b68","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-longer-trial","predicate":"does_not_increase_tested","statement":"A 12-week 6 g/day trial in trained men found no testosterone benefit or added strength/hypertrophy benefit over placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c6eb3a98-d085-53c4-82e4-4cca7c594669","mechanism_event_label":"The longer higher-dose trial also failed to show a testosterone advantage.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c6eb3a98-d085-53c4-82e4-4cca7c594669","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-longer-trial-event","event_type":"observed_relationship","label":"The longer higher-dose trial also failed to show a testosterone advantage.","description":"A 12-week 6 g/day trial in trained men found no testosterone benefit or added strength/hypertrophy benefit over placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e78f545c-d4f7-53a4-b575-56c8fdb8b470","slug":"circulating-free-testosterone","display_name":"Circulating free testosterone concentration","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"22 randomized, 19 completed; resistance training four days weekly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Overlapping investigators with the 2015 trial; not independent laboratory replication. Hormonal and training endpoints are distinct.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The longer higher-dose trial also failed to show a testosterone advantage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28841667/ · DOI 10.1371/journal.pone.0182630","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"02bb3e99-bde2-53bb-8b97-fdcf82967a68","evidence_kind":"source_excerpt","locator":"Lines 352-358","start_line":352,"end_line":358,"excerpt":"## d-aspartate-human-longer-trial\nThe longer higher-dose trial also failed to show a testosterone advantage.\nA 12-week 6 g/day trial in trained men found no testosterone benefit or added strength/hypertrophy benefit over placebo.\nModel: 22 randomized, 19 completed; resistance training four days weekly.\nLimitations: Overlapping investigators with the 2015 trial; not independent laboratory replication. Hormonal and training endpoints are distinct.\nEvidence access: Primary full text\nThe effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28841667/ · DOI 10.1371/journal.pone.0182630","model_system":"22 randomized, 19 completed; resistance training four days weekly.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0a86a1008edb8a69dcc79409e76e3fd5ce59b0747be8cae8f21e43f871e76248","revision_id":"a1de4b66-263d-5452-8ed8-df853afba030","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}