{"id":"ea77067e-233e-5890-8272-ebbe9977f33d","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-parent-urine","predicate":"reported_relationship","statement":"The same aglycone exposure yielded 0.9 ± 0.6 micromoles of measured urinary glucuronides over 24 hours, about 0.5% of intake.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"37f97440-1e17-50b8-be7e-44726a885e41","mechanism_event_label":"The same aglycone exposure yielded 0.9 ± 0.6 micromoles of measured urinary glucuronides over 24 hours, about 0.5% of intake.","subject":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"object":{"id":"5f06e339-09cd-5beb-8796-faf1933f8463","slug":"apigenin-human-urinary-conjugates","display_name":"Human urinary apigenin conjugate recovery","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"37f97440-1e17-50b8-be7e-44726a885e41","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-parent-urine-event","event_type":"experimental_observation","label":"The same aglycone exposure yielded 0.9 ± 0.6 micromoles of measured urinary glucuronides over 24 hours, about 0.5% of intake.","description":"### api-parent-urine\n\nThe same aglycone exposure yielded 0.9 ± 0.6 micromoles of measured urinary glucuronides over 24 hours, about 0.5% of intake.\nRecovery of selected metabolites is not an absolute bioavailability measurement.\nModel and exposure: Three healthy men; authentic-standard HPLC-MS.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"5f06e339-09cd-5beb-8796-faf1933f8463","slug":"apigenin-human-urinary-conjugates","display_name":"Human urinary apigenin conjugate recovery","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"070686a8-425a-59da-b2d4-cacd7f73b711","slug":"apigenin-4-prime-glucuronide","display_name":"Apigenin 4′-O-glucuronide","entity_type_key":"small_molecule"},"role":"measured product","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"353de06b-4efb-5810-a466-8f1056a30ecb","slug":"apigenin-7-glucuronide","display_name":"Apigenin 7-O-glucuronide","entity_type_key":"small_molecule"},"role":"measured product","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three healthy men; authentic-standard HPLC-MS.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same aglycone exposure yielded 0.9 ± 0.6 micromoles of measured urinary glucuronides over 24 hours, about 0.5% of intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-parent-urine; Recovery of selected metabolites is not an absolute bioavailability measurement.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"deb79744-0390-53be-8d12-eeaca3ccb43f","evidence_kind":"source_excerpt","locator":"Lines 37-43","start_line":37,"end_line":43,"excerpt":"### api-parent-urine\n\nThe same aglycone exposure yielded 0.9 ± 0.6 micromoles of measured urinary glucuronides over 24 hours, about 0.5% of intake.\nRecovery of selected metabolites is not an absolute bioavailability measurement.\nModel and exposure: Three healthy men; authentic-standard HPLC-MS.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","model_system":"Three healthy men; authentic-standard HPLC-MS.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}