{"id":"ea39a61b-9000-57b7-8b31-4bfe3b93f354","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:human-k-withdrawal-increases-calciuria","predicate":"deprivation-increases","statement":"Five-day dietary potassium withdrawal increased fasting and daily urinary calcium excretion whether the withdrawn salt was KCl or KHCO3.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"43214762-6fe9-5d46-8b9d-76fa762e9f79","mechanism_event_label":"Potassium deprivation changed calcium retention even when alkali withdrawal was not the only explanation.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"538fbe5c-11da-5aa5-990f-e8be1aa7bc5a","slug":"urinary-calcium-excretion","display_name":"Urinary calcium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43214762-6fe9-5d46-8b9d-76fa762e9f79","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:human-k-withdrawal-increases-calciuria-event","event_type":"biochemical_relationship","label":"Potassium deprivation changed calcium retention even when alkali withdrawal was not the only explanation.","description":"Five-day dietary potassium withdrawal increased fasting and daily urinary calcium excretion whether the withdrawn salt was KCl or KHCO3.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"upstream","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"538fbe5c-11da-5aa5-990f-e8be1aa7bc5a","slug":"urinary-calcium-excretion","display_name":"Urinary calcium excretion","entity_type_key":"cellular_process"},"role":"downstream","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"measured-ion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"role":"withdrawn-salt","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5de32c9c-ee6a-506f-8e94-efd1698f434e","slug":"potassium-bicarbonate","display_name":"Potassium bicarbonate","entity_type_key":"chemical_species"},"role":"withdrawn-salt","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Potassium deprivation increases renal calcium loss in a controlled human dietary model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"Five-day dietary potassium withdrawal increased fasting and daily urinary calcium excretion whether the withdrawn salt was KCl or KHCO3.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental-exposure","value_text":"Healthy adults on controlled diets; salt loading in ten participants and five-day potassium deprivation with recovery in two groups of four.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy adults on controlled diets; salt loading in ten participants and five-day potassium deprivation with recovery in two groups of four.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small controlled metabolic study; sodium balance, extracellular volume, phosphate handling and calcitriol were possible mediators rather than proven causal links.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Potassium deprivation changed calcium retention even when alkali withdrawal was not the only explanation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lemann-1991-calciuria] Potassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults [corrected] (1991). https://pubmed.ncbi.nlm.nih.gov/1648646/ DOI: 10.1038/ki.1991.123","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"kidney and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"28f27439-9a42-5690-9984-85ca859d17bc","evidence_kind":"source_excerpt","locator":"Lines 1274-1286","start_line":1274,"end_line":1286,"excerpt":"### human-k-withdrawal-increases-calciuria\nFive-day dietary potassium withdrawal increased fasting and daily urinary calcium excretion whether the withdrawn salt was KCl or KHCO3.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Potassium deprivation changed calcium retention even when alkali withdrawal was not the only explanation.\norganism: Homo sapiens\ntissue_or_cell_type: kidney and urine\nexperimental_model: Healthy adults on controlled diets; salt loading in ten participants and five-day potassium deprivation with recovery in two groups of four.\nlimitations: Small controlled metabolic study; sodium balance, extracellular volume, phosphate handling and calcitriol were possible mediators rather than proven causal links.\ncross_nutrient: Potassium deprivation increases renal calcium loss in a controlled human dietary model.\nexperimental-exposure: Healthy adults on controlled diets; salt loading in ten participants and five-day potassium deprivation with recovery in two groups of four.\nendpoint: Five-day dietary potassium withdrawal increased fasting and daily urinary calcium excretion whether the withdrawn salt was KCl or KHCO3.\n[lemann-1991-calciuria] Potassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults [corrected] (1991). https://pubmed.ncbi.nlm.nih.gov/1648646/ DOI: 10.1038/ki.1991.123","model_system":"Healthy adults on controlled diets; salt loading in ten participants and five-day potassium deprivation with recovery in two groups of four.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lemann-1991-calciuria] Potassium administration reduces and potassium deprivation increases urinary calcium excretion in healthy adults [corrected] (1991). https://pubmed.ncbi.nlm.nih.gov/1648646/ DOI: 10.1038/ki.1991.123","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}