{"id":"e9c04abb-d1d4-55e7-8ed0-8a37d0ff670b","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-hericenone-b-platelets","predicate":"selectively_inhibits","statement":"Hericenone B inhibited collagen-induced aggregation in washed rabbit and human platelets but did not inhibit aggregation induced by U46619, ADP, thrombin, adrenaline, arachidonic acid or convulxin.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b9c782d3-1752-5d3a-ab41-bfbecea0c972","mechanism_event_label":"Hericenone B inhibited collagen-induced aggregation in washed rabbit and human platelets but did not inhibit aggregation induced by U46619, ADP, thrombin, adrenaline, arachidonic acid or convulxin.","subject":{"id":"02b65df6-3476-5c42-b8b7-646eb39f82ac","slug":"hericenone-b","display_name":"Hericenone B","entity_type_key":"small_molecule"},"object":{"id":"dbf54736-6343-50ef-b319-6b171c925617","slug":"collagen-induced-human-platelet-aggregation","display_name":"Collagen-induced human platelet aggregation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b9c782d3-1752-5d3a-ab41-bfbecea0c972","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-hericenone-b-platelets-event","event_type":"observed_relationship","label":"Hericenone B inhibited collagen-induced aggregation in washed rabbit and human platelets but did not inhibit aggregation induced by U46619, ADP, thrombin, adrenaline, arachidonic acid or convulxin.","description":"Hericenone B inhibited collagen-induced aggregation in washed rabbit and human platelets but did not inhibit aggregation induced by U46619, ADP, thrombin, adrenaline, arachidonic acid or convulxin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"02b65df6-3476-5c42-b8b7-646eb39f82ac","slug":"hericenone-b","display_name":"Hericenone B","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dbf54736-6343-50ef-b319-6b171c925617","slug":"collagen-induced-human-platelet-aggregation","display_name":"Collagen-induced human platelet aggregation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15408bf1-872e-56f3-8a8d-b512624ecec0","slug":"collagen","display_name":"Collagen","entity_type_key":"protein_set"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"136c3764-1b93-5f79-8673-9001cab9bc3d","slug":"adp","display_name":"Adenosine diphosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Purified hericenone B with multiple agonists","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Washed rabbit and human platelets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed integrin-alpha2/beta1-to-arachidonate step was not a human oral antithrombotic trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hericenones-erinacines","display_name":"Hericenones and erinacines","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Washed rabbit and human platelets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Hericenone B inhibited collagen-induced aggregation in washed rabbit and human platelets but did not inhibit aggregation induced by U46619, ADP, thrombin, adrenaline, arachidonic acid or convulxin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. (2010). https://pubmed.ncbi.nlm.nih.gov/20637576/ DOI: 10.1016/j.phymed.2010.05.004","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Agonist-specific platelet aggregation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2c1f674b-26dd-51d6-b6ae-7650a88c173e","evidence_kind":"source_excerpt","locator":"Lines 55-64","start_line":55,"end_line":64,"excerpt":"## hericenones-erinacines-hericenone-b-platelets\nHericenone B inhibited collagen-induced aggregation in washed rabbit and human platelets but did not inhibit aggregation induced by U46619, ADP, thrombin, adrenaline, arachidonic acid or convulxin.\nModel/species: Washed rabbit and human platelets\nTissue/system: Agonist-specific platelet aggregation\nExposure: Purified hericenone B with multiple agonists\nRoute: In vitro\nDuration: Acute\nLimits: The proposed integrin-alpha2/beta1-to-arachidonate step was not a human oral antithrombotic trial.\nPrimary reference: Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. (2010). https://pubmed.ncbi.nlm.nih.gov/20637576/ DOI: 10.1016/j.phymed.2010.05.004\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Washed rabbit and human platelets","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"aa7c09fd-ab4a-51ff-b463-d35547dc41ba","stable_key":"import-d39c4b36-9a88-5f52-8e6b-93a248dc4bfc","title":"Hericenones & Erinacines: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"f1ff2966f222f5c463e8e509ec1b1642a0053cd38f121f3847cdd21855c46e85","revision_id":"d00076e0-da87-5100-92ed-0525190b25a1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}