{"id":"e93e53d0-0d4b-5232-aded-26ea1101c073","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-hepcidin-fpn-removal","predicate":"reduces","statement":"Hepcidin binding induced ferroportin internalization and degradation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a7029f22-b11c-5304-b68c-3ffdfdf5c4a0","mechanism_event_label":"The cell removes the exit route for iron from its surface.","subject":{"id":"6d4be6b8-eba9-5d6b-93f9-4642b87f7b6f","slug":"hamp","display_name":"Hepcidin","entity_type_key":"protein"},"object":{"id":"58522adf-cfd1-5584-b06a-a94304fc7974","slug":"ferroportin-surface-abundance","display_name":"Cell-surface ferroportin abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a7029f22-b11c-5304-b68c-3ffdfdf5c4a0","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-hepcidin-fpn-removal-event","event_type":"biochemical_relationship","label":"The cell removes the exit route for iron from its surface.","description":"Hepcidin binding induced ferroportin internalization and degradation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2210be14-d81c-5a26-a3fb-5b566f47f1fd","slug":"slc40a1","display_name":"Ferroportin / SLC40A1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6d4be6b8-eba9-5d6b-93f9-4642b87f7b6f","slug":"hamp","display_name":"Hepcidin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58522adf-cfd1-5584-b06a-a94304fc7974","slug":"ferroportin-surface-abundance","display_name":"Cell-surface ferroportin abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/15514116.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\", \"start_char\": 0, \"end_char\": 758, \"text_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Hepcidin binding and cellular export experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Hepcidin exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Post-translational export regulation; no dose-response to dietary iron is inferred from the cell experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Tissue-culture ferroportin systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cell removes the exit route for iron from its surface.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. (2004). https://pubmed.ncbi.nlm.nih.gov/15514116/ DOI: 10.1126/science.1104742","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f53b2b66-0bb7-509d-a940-c67fc672f811","evidence_kind":"source_excerpt","locator":"Lines 719-730","start_line":719,"end_line":730,"excerpt":"### iron-hepcidin-fpn-removal\nHepcidin binding induced ferroportin internalization and degradation.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The cell removes the exit route for iron from its surface.\norganism: Tissue-culture ferroportin systems\ntissue_or_cell_type: Plasma membrane\nexperimental_model: Hepcidin binding and cellular export experiments\nlimitations: Post-translational export regulation; no dose-response to dietary iron is inferred from the cell experiment.\nexposure: Hepcidin exposure\nevidence_span: {\"source_cache\": \"artifacts/iron-research/15514116.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\", \"start_char\": 0, \"end_char\": 758, \"text_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\"}\n[iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. 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