{"id":"e928dd37-aa4c-58ff-b7da-c491d0221756","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-tcpo2-rise","predicate":"increases","statement":"Transcutaneous oxygen tension measured on the dorsum of the foot rose significantly more in the treated group, by 14.0 mmHg versus 5.0 mmHg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a6fb7a97-49a2-5bb5-bcfa-4788bbff7bf5","mechanism_event_label":"The treatment measurably raised the oxygen reaching the skin of the foot.","subject":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"object":{"id":"f5a72e71-ec22-5fc1-85dd-39b82e598176","slug":"transcutaneous-oxygen-tension","display_name":"Transcutaneous oxygen tension on the foot","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a6fb7a97-49a2-5bb5-bcfa-4788bbff7bf5","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-tcpo2-rise-event","event_type":"observed_intervention","label":"The treatment measurably raised the oxygen reaching the skin of the foot.","description":"Transcutaneous oxygen tension measured on the dorsum of the foot rose significantly more in the treated group, by 14.0 mmHg versus 5.0 mmHg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5bd372d7-e3d3-5b39-96ce-645b4e90522e","slug":"tissue-oxygen-tension","display_name":"Tissue oxygen tension","entity_type_key":"cellular_process"},"role":"measured_property","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f5a72e71-ec22-5fc1-85dd-39b82e598176","slug":"transcutaneous-oxygen-tension","display_name":"Transcutaneous oxygen tension on the foot","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/hbot-research/8941460.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2f2904fa77e07a14257977ef8ca30fc46ee5ada35e65be2cc6512161bd0b440e\", \"start_char\": 0, \"end_char\": 1910, \"text_sha256\": \"2f2904fa77e07a14257977ef8ca30fc46ee5ada35e65be2cc6512161bd0b440e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomised study of 70 people admitted with severe prevalently ischaemic diabetic foot ulcer","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Systemic hyperbaric oxygen, mean 38.8 sessions, added to a full treatment protocol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A single-centre randomised study with amputation as the endpoint. 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Adjunctive to an aggressive protocol, so the effect is of the addition, not of hyperbaric oxygen alone.\nexposure: Systemic hyperbaric oxygen, mean 38.8 sessions, added to a full treatment protocol\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/8941460.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2f2904fa77e07a14257977ef8ca30fc46ee5ada35e65be2cc6512161bd0b440e\", \"start_char\": 0, \"end_char\": 1910, \"text_sha256\": \"2f2904fa77e07a14257977ef8ca30fc46ee5ada35e65be2cc6512161bd0b440e\"}\n[hbot-p8941460] Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. (1996). https://pubmed.ncbi.nlm.nih.gov/8941460/ DOI: 10.2337/diacare.19.12.1338","model_system":"Randomised study of 70 people admitted with severe prevalently ischaemic diabetic foot ulcer","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hbot-p8941460] Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. 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