{"id":"e90eea89-13c3-56e3-8116-8218a811e525","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-neuron-diet-limits","predicate":"partially_rescues","statement":"Dietary alanine supplementation improved survival and brain metabolic profiles in Gpt2-null mice but did not alone appear to correct motor function.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"405e4367-3b1d-5ff2-8ea9-9aa136fe68ec","mechanism_event_label":"Restoring a metabolite helped some outcomes while leaving major problems unresolved.","subject":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"object":{"id":"0baf2313-08ec-5f91-b508-2e258814c3ab","slug":"mouse-gpt2-null-survival-motor","display_name":"Survival and motor outcomes in Gpt2-null mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"405e4367-3b1d-5ff2-8ea9-9aa136fe68ec","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-neuron-diet-limits-event","event_type":"observed_relationship","label":"Restoring a metabolite helped some outcomes while leaving major problems unresolved.","description":"Dietary alanine supplementation improved survival and brain metabolic profiles in Gpt2-null mice but did not alone appear to correct motor function.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0baf2313-08ec-5f91-b508-2e258814c3ab","slug":"mouse-gpt2-null-survival-motor","display_name":"Survival and motor outcomes in Gpt2-null mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f78af6f3-4504-551f-b48b-dd25fcf5a629","slug":"mouse-gpt2","display_name":"Mouse mitochondrial alanine aminotransferase / Gpt2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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