{"id":"e8c62a55-1fa7-5ed7-8489-92244f4a7c45","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-acute-glucose","predicate":"impairs_acutely","statement":"Melatonin impaired glucose tolerance during both morning and evening challenges.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"458010d9-0e06-5707-b246-3528617ab348","mechanism_event_label":"Melatonin exposure close to carbohydrate intake can matter metabolically.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"458010d9-0e06-5707-b246-3528617ab348","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-acute-glucose-event","event_type":"observed_intervention","label":"Melatonin exposure close to carbohydrate intake can matter metabolically.","description":"Melatonin impaired glucose tolerance during both morning and evening challenges.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/25197811.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a2ed431f069ffbe6ace434aba258b90c154b1d07e4c6b92816cba26bb3b31c04\", \"start_char\": 0, \"end_char\": 1466, \"text_sha256\": \"a2ed431f069ffbe6ace434aba258b90c154b1d07e4c6b92816cba26bb3b31c04\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-blind placebo-controlled glucose challenges","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5 mg melatonin 15 minutes before 75 g OGTT at 09:00 or 21:00","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute high-exposure challenge; not evidence that every bedtime regimen causes diabetes. Estimated mechanisms varied by time of day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"21 healthy young women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Melatonin exposure close to carbohydrate intake can matter metabolically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p25197811] Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. (2014). https://pubmed.ncbi.nlm.nih.gov/25197811/ DOI: 10.5665/sleep.4088","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oral glucose tolerance in morning and evening","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d79ce25e-4fdf-5ef8-903f-a9b4eee2ad1b","evidence_kind":"source_excerpt","locator":"Lines 1059-1070","start_line":1059,"end_line":1070,"excerpt":"### melatonin-acute-glucose\nMelatonin impaired glucose tolerance during both morning and evening challenges.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Melatonin exposure close to carbohydrate intake can matter metabolically.\norganism: 21 healthy young women\ntissue_or_cell_type: Oral glucose tolerance in morning and evening\nexperimental_model: Single-blind placebo-controlled glucose challenges\nlimitations: Acute high-exposure challenge; not evidence that every bedtime regimen causes diabetes. Estimated mechanisms varied by time of day.\nexposure: 5 mg melatonin 15 minutes before 75 g OGTT at 09:00 or 21:00\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/25197811.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a2ed431f069ffbe6ace434aba258b90c154b1d07e4c6b92816cba26bb3b31c04\", \"start_char\": 0, \"end_char\": 1466, \"text_sha256\": \"a2ed431f069ffbe6ace434aba258b90c154b1d07e4c6b92816cba26bb3b31c04\"}\n[melatonin-p25197811] Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. (2014). https://pubmed.ncbi.nlm.nih.gov/25197811/ DOI: 10.5665/sleep.4088","model_system":"Single-blind placebo-controlled glucose challenges","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p25197811] Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. (2014). https://pubmed.ncbi.nlm.nih.gov/25197811/ DOI: 10.5665/sleep.4088","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}