{"id":"e898d755-0a15-51ee-87b5-3c589c36bf72","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-osgepl1-fidelity","predicate":"when_deleted_increases","statement":"Mitochondrial t6A37 hypomodification after OSGEPL1 deletion caused near-cognate codon misreading and amino-acid misincorporation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"71f890b8-057c-5a3c-babc-21e58de4fb73","mechanism_event_label":"Loss of an RNA mark can change translation accuracy as well as speed.","subject":{"id":"f28550d6-0143-5fe3-ae30-1e634dbd024d","slug":"osgepl1","display_name":"Human mitochondrial tRNA threonylcarbamoyltransferase / OSGEPL1","entity_type_key":"protein"},"object":{"id":"0d858080-ceef-597c-a9ec-2c5995eb7418","slug":"human-mitochondrial-near-cognate-misreading","display_name":"Human mitochondrial near-cognate codon misreading","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"71f890b8-057c-5a3c-babc-21e58de4fb73","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-osgepl1-fidelity-event","event_type":"observed_relationship","label":"Loss of an RNA mark can change translation accuracy as well as speed.","description":"Mitochondrial t6A37 hypomodification after OSGEPL1 deletion caused near-cognate codon misreading and amino-acid misincorporation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f28550d6-0143-5fe3-ae30-1e634dbd024d","slug":"osgepl1","display_name":"Human mitochondrial tRNA threonylcarbamoyltransferase / OSGEPL1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0d858080-ceef-597c-a9ec-2c5995eb7418","slug":"human-mitochondrial-near-cognate-misreading","display_name":"Human mitochondrial near-cognate codon misreading","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5c27b149-da7e-5a90-8bd3-d4b2a42bb2ef","slug":"trna-threonylcarbamoyladenosine","display_name":"tRNA-bound N6-threonylcarbamoyladenosine / t6A37","entity_type_key":"rna"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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