{"id":"e84688ab-41fc-5096-bb60-b94d02448d59","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-methylcobalamin-diabetes-cognition","predicate":"did_not_significantly_change_cognitive_decline","statement":"At 27 months, groups did not differ significantly in change in Clinical Dementia Rating or neuropsychological test z-scores.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d03f2f34-0774-5fd5-916b-ce368028e1f1","mechanism_event_label":"Better markers did not establish protection from cognitive decline in this group.","subject":{"id":"6563fbad-ebdc-5408-966a-d24f8b8cd854","slug":"methylcobalamin","display_name":"Methylcobalamin","entity_type_key":"small_molecule"},"object":{"id":"bea41843-ea4a-5399-995b-2e36d6807a97","slug":"clinical-dementia-rating","display_name":"Clinical Dementia Rating score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d03f2f34-0774-5fd5-916b-ce368028e1f1","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-methylcobalamin-diabetes-cognition-event","event_type":"observed_intervention","label":"Better markers did not establish protection from cognitive decline in this group.","description":"At 27 months, groups did not differ significantly in change in Clinical Dementia Rating or neuropsychological test z-scores.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"410810cc-e31d-5dc4-ac2a-9181bc413591","slug":"neuropsychological-test-performance","display_name":"Neuropsychological test performance","entity_type_key":"cellular_process"},"role":"secondary_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6563fbad-ebdc-5408-966a-d24f8b8cd854","slug":"methylcobalamin","display_name":"Methylcobalamin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bea41843-ea4a-5399-995b-2e36d6807a97","slug":"clinical-dementia-rating","display_name":"Clinical Dementia Rating score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled trial: 271 nondemented diabetic outpatients aged at least 70, plasma B12 150–300 pmol/L.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral methylcobalamin 1000 micrograms/day versus placebo for 27 months.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"More smokers were randomized to active treatment; excluding smokers did not change the reported result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Better markers did not establish protection from cognitive decline in this group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b12-kwok2017] A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12 (2017). https://pubmed.ncbi.nlm.nih.gov/27823800/ DOI: 10.1016/j.clnu.2016.10.018","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"fd2e8493-f96f-54bb-994e-1c661964c464","evidence_kind":"source_excerpt","locator":"Lines 1573-1583","start_line":1573,"end_line":1583,"excerpt":"### b12-methylcobalamin-diabetes-cognition\nAt 27 months, groups did not differ significantly in change in Clinical Dementia Rating or neuropsychological test z-scores.\nCondition category: biomarker_context\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Better markers did not establish protection from cognitive decline in this group.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Randomized placebo-controlled trial: 271 nondemented diabetic outpatients aged at least 70, plasma B12 150–300 pmol/L.\nlimitations: More smokers were randomized to active treatment; excluding smokers did not change the reported result.\nexposure: Oral methylcobalamin 1000 micrograms/day versus placebo for 27 months.\n[b12-kwok2017] A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12 (2017). https://pubmed.ncbi.nlm.nih.gov/27823800/ DOI: 10.1016/j.clnu.2016.10.018","model_system":"Randomized placebo-controlled trial: 271 nondemented diabetic outpatients aged at least 70, plasma B12 150–300 pmol/L.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-kwok2017] A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12 (2017). https://pubmed.ncbi.nlm.nih.gov/27823800/ DOI: 10.1016/j.clnu.2016.10.018","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}