{"id":"e8202dd5-2a1f-5af3-8023-84c86e0337e5","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-blood-pressure-trial","predicate":"reduces","statement":"A two-year placebo-controlled trial in mild hypertension reported lower blood pressure with 500 mg stevioside three times daily; 174 enrolled and 168 completed.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7112f79a-5b9c-51e1-84e4-2fb956c6eaa6","mechanism_event_label":"A pharmacological-style oral regimen produced a clinical signal in one study.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"8c8f1119-e936-5593-884a-375602c1391c","slug":"human-stevioside-blood-pressure","display_name":"Human blood pressure during long-term stevioside","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7112f79a-5b9c-51e1-84e4-2fb956c6eaa6","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-blood-pressure-trial-event","event_type":"observed_relationship","label":"A pharmacological-style oral regimen produced a clinical signal in one study.","description":"A two-year placebo-controlled trial in mild hypertension reported lower blood pressure with 500 mg stevioside three times daily; 174 enrolled and 168 completed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8c8f1119-e936-5593-884a-375602c1391c","slug":"human-stevioside-blood-pressure","display_name":"Human blood pressure during long-term stevioside","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter randomized double-blind trial in Chinese adults with mild essential hypertension.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Gram-level daily exposure; this does not verify calcium-channel mediation in humans or make every stevia product an antihypertensive.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A pharmacological-style oral regimen produced a clinical signal in one study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14693305/ · DOI 10.1016/s0149-2918(03)80334-x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2d6a2efd-d08c-5ec3-b5de-f49b8b90acf5","evidence_kind":"source_excerpt","locator":"Lines 386-392","start_line":386,"end_line":392,"excerpt":"## stevia-blood-pressure-trial\nA pharmacological-style oral regimen produced a clinical signal in one study.\nA two-year placebo-controlled trial in mild hypertension reported lower blood pressure with 500 mg stevioside three times daily; 174 enrolled and 168 completed.\nModel: Multicenter randomized double-blind trial in Chinese adults with mild essential hypertension.\nLimitations: Gram-level daily exposure; this does not verify calcium-channel mediation in humans or make every stevia product an antihypertensive.\nEvidence access: Primary abstract\nEfficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14693305/ · DOI 10.1016/s0149-2918(03)80334-x","model_system":"Multicenter randomized double-blind trial in Chinese adults with mild essential hypertension.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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