{"id":"e7d9f320-e2e6-5159-bc77-4c13b3a16ea8","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:two-months-of-supplementation-lowers-factor-vii","predicate":"reduces","statement":"Factor VII declined by 7 to 14% over the same two months.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4cdc2a12-fc14-5f6d-97b9-5d731f3c252b","mechanism_event_label":"Factor VII declined by 7 to 14% over the same two months.","subject":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"0f797a11-a3ca-58ef-a6b1-bfe002502748","slug":"f7","display_name":"Human coagulation factor VII / F7","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"4cdc2a12-fc14-5f6d-97b9-5d731f3c252b","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:two-months-of-supplementation-lowers-factor-vii-event","event_type":"observed_intervention","label":"Factor VII declined by 7 to 14% over the same two months.","description":"Plasma","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f797a11-a3ca-58ef-a6b1-bfe002502748","slug":"f7","display_name":"Human coagulation factor VII / F7","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"2 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (45 subjects across three groups)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase, 4,000 FU per day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"As above. Direct proteolytic cleavage of factor VII by purified nattokinase has not been shown, so this association has no identified molecular step behind it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (45 subjects across three groups)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Factor VII declined by 7 to 14% over the same two months.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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