{"id":"e7d7f894-9aba-50b7-bbd8-f38b50204f8b","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-prediabetes-metabolic-null","predicate":"does_not_change","statement":"The same 12-week trial found no between-group differences in gut microbiota composition, hepatic or renal function markers, or the measured appetite-controlling hormones.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"fe64547f-5289-54f9-af1f-27daba117290","mechanism_event_label":"The same 12-week trial found no between-group differences in gut microbiota composition, hepatic or renal function markers, or the measured appetite-controlling hormones.","subject":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"object":{"id":"219a0389-8f89-5e7d-ae62-dba867bf21ce","slug":"human-prediabetes-microbiota-organ-appetite-panel","display_name":"Gut microbiota, hepatic/renal markers and appetite-hormone panel in prediabetes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fe64547f-5289-54f9-af1f-27daba117290","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-prediabetes-metabolic-null-event","event_type":"observed_relationship","label":"The same 12-week trial found no between-group differences in gut microbiota composition, hepatic or renal function markers, or the measured appetite-controlling hormones.","description":"The same 12-week trial found no between-group differences in gut microbiota composition, hepatic or renal function markers, or the measured appetite-controlling hormones.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"219a0389-8f89-5e7d-ae62-dba867bf21ce","slug":"human-prediabetes-microbiota-organ-appetite-panel","display_name":"Gut microbiota, hepatic/renal markers and appetite-hormone panel in prediabetes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"2.4 g/day dry leaf powder or placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Adults with prediabetes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The null applies to the measured endpoints, sample and exposure; it does not establish that every product is inert.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"moringa","display_name":"Moringa oleifera","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Adults with prediabetes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same 12-week trial found no between-group differences in gut microbiota composition, hepatic or renal function markers, or the measured appetite-controlling hormones.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes. (2021). https://pubmed.ncbi.nlm.nih.gov/35010932/ DOI: 10.3390/nu14010057","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Microbiota, organ-function markers and appetite hormones","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"513c94ee-917e-5bf1-8256-3aecd5131b86","evidence_kind":"source_excerpt","locator":"Lines 145-154","start_line":145,"end_line":154,"excerpt":"## moringa-prediabetes-metabolic-null\nThe same 12-week trial found no between-group differences in gut microbiota composition, hepatic or renal function markers, or the measured appetite-controlling hormones.\nModel/species: Adults with prediabetes\nTissue/system: Microbiota, organ-function markers and appetite hormones\nExposure: 2.4 g/day dry leaf powder or placebo\nRoute: Oral\nDuration: 12 weeks\nLimits: The null applies to the measured endpoints, sample and exposure; it does not establish that every product is inert.\nPrimary reference: Moringa oleifera Leaf Supplementation as a Glycemic Control Strategy in Subjects with Prediabetes. (2021). https://pubmed.ncbi.nlm.nih.gov/35010932/ DOI: 10.3390/nu14010057\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Adults with prediabetes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"c4146a85ed4997fa117a83862fcf605ffb74110cf9f9cac8c63d1f6b07b8a57c","revision_id":"399ef3a4-8939-5df0-9f90-71d41dd6bab8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}