{"id":"e78fdf3b-c008-54d0-b0f5-880f30fc78d4","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-colitis","predicate":"feeding_promotes","statement":"Taurocholic-acid feeding promoted colitis in Il10-null mice; milk-fat-associated microbial expansion and inflammation depended on host susceptibility.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a79f1b61-b29c-52b2-897e-c88b09debc78","mechanism_event_label":"A sulfur-using microbial route worsened inflammation in this susceptible model.","subject":{"id":"4f4ae3d8-b415-53b7-8262-46d90815a0c9","slug":"taurocholate","display_name":"Taurocholate","entity_type_key":"small_molecule"},"object":{"id":"6fc2b227-82df-5fbf-84ea-82cdd513f4fd","slug":"mouse-il10-null-colitis","display_name":"Colitis in Il10-null mice in the taurocholate study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a79f1b61-b29c-52b2-897e-c88b09debc78","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-colitis-event","event_type":"observed_relationship","label":"A sulfur-using microbial route worsened inflammation in this susceptible model.","description":"Taurocholic-acid feeding promoted colitis in Il10-null mice; milk-fat-associated microbial expansion and inflammation depended on host susceptibility.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4f4ae3d8-b415-53b7-8262-46d90815a0c9","slug":"taurocholate","display_name":"Taurocholate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6fc2b227-82df-5fbf-84ea-82cdd513f4fd","slug":"mouse-il10-null-colitis","display_name":"Colitis in Il10-null mice in the taurocholate study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d4efdf7e-a484-5c49-a89a-e76975139b52","slug":"bilophila-wadsworthia","display_name":"Bilophila wadsworthia","entity_type_key":"organism"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Il10-deficient and wild-type mouse comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a demonstration that taurine causes human inflammatory bowel disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A sulfur-using microbial route worsened inflammation in this susceptible model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22722865/ · DOI 10.1038/nature11225","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7964f0fa-0d2e-5069-9095-120d8e1ea3d1","evidence_kind":"source_excerpt","locator":"Lines 337-343","start_line":337,"end_line":343,"excerpt":"## taurine-microbial-colitis\nA sulfur-using microbial route worsened inflammation in this susceptible model.\nTaurocholic-acid feeding promoted colitis in Il10-null mice; milk-fat-associated microbial expansion and inflammation depended on host susceptibility.\nModel: Il10-deficient and wild-type mouse comparisons.\nLimitations: Not a demonstration that taurine causes human inflammatory bowel disease.\nEvidence access: Primary abstract\nDietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22722865/ · DOI 10.1038/nature11225","model_system":"Il10-deficient and wild-type mouse comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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