{"id":"e7773d37-a455-5c91-96d9-719b369a6359","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-il8","predicate":"reduces","statement":"Astaxanthin reduced H. pylori-induced ROS, NF-kappa-B activation and IL-8 expression in human AGS cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"04aa398c-c809-5321-8952-e919c8a9490d","mechanism_event_label":"The challenged gastric cells produced a smaller inflammatory signal.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"04aa398c-c809-5321-8952-e919c8a9490d","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-il8-event","event_type":"observed_relationship","label":"The challenged gastric cells produced a smaller inflammatory signal.","description":"Astaxanthin reduced H. pylori-induced ROS, NF-kappa-B activation and IL-8 expression in human AGS cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"875a94da-1eee-50d2-b5c1-e4316c2a8f45","slug":"nf-kappab-signaling","display_name":"NF-kappa-B signaling","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human gastric adenocarcinoma cell line, H. pylori challenge.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a clinical eradication trial and not proof of identical behavior in normal gastric tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The challenged gastric cells produced a smaller inflammatory signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0248e08-2053-5cda-a215-24c5f3af3697","evidence_kind":"source_excerpt","locator":"Lines 294-300","start_line":294,"end_line":300,"excerpt":"## astaxanthin-gastric-il8\nThe challenged gastric cells produced a smaller inflammatory signal.\nAstaxanthin reduced H. pylori-induced ROS, NF-kappa-B activation and IL-8 expression in human AGS cells.\nModel: Human gastric adenocarcinoma cell line, H. pylori challenge.\nLimitations: Not a clinical eradication trial and not proof of identical behavior in normal gastric tissue.\nEvidence access: Primary abstract\nAstaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","model_system":"Human gastric adenocarcinoma cell line, H. pylori challenge.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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