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Probe metabolic ratios are not percentage inhibition of every substrate. No universal dose-adjustment rule; no statistically significant effect is not equivalence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Berberine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy human male volunteers; 17 completed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A human probe study measured slower metabolism through CYP2D6.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[berberine-p21870106] Repeated administration of berberine inhibits cytochromes P450 in humans. 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Probe metabolic ratios are not percentage inhibition of every substrate. No universal dose-adjustment rule; no statistically significant effect is not equivalence.\nexposure: Berberine 300 mg three times daily for 14 days versus placebo\nevidence_span: {\"source_cache\": \"artifacts/berberine-research/21870106.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"12e465c3c0a8ce995697a6fb9bf77c079e38b413e82c8b4f2a82e45a3dbf8ae5\", \"start_char\": 0, \"end_char\": 1817, \"text_sha256\": \"12e465c3c0a8ce995697a6fb9bf77c079e38b413e82c8b4f2a82e45a3dbf8ae5\"}\n[berberine-p21870106] Repeated administration of berberine inhibits cytochromes P450 in humans. 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