{"id":"e70ec3e2-20ed-5bca-86ff-29614c2920d0","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-renal-reabsorption","predicate":"undergoes_reported","statement":"Very low renal clearance of SAC, below 0.01 L/h/kg, supported extensive reabsorption in rats and dogs.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5b8d953d-10cb-52cf-8e7c-1839232800e2","mechanism_event_label":"Kidney handling helps explain persistence in blood.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"bea5986f-9e27-5dda-9a7d-1f5cda41a85c","slug":"animal-sac-renal-reabsorption","display_name":"SAC renal reabsorption in rat and dog PK studies","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5b8d953d-10cb-52cf-8e7c-1839232800e2","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-renal-reabsorption-event","event_type":"observed_relationship","label":"Kidney handling helps explain persistence in blood.","description":"Very low renal clearance of SAC, below 0.01 L/h/kg, supported extensive reabsorption in rats and dogs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bea5986f-9e27-5dda-9a7d-1f5cda41a85c","slug":"animal-sac-renal-reabsorption","display_name":"SAC renal reabsorption in rat and dog PK studies","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Rats 5 mg/kg; dogs 2 mg/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Single administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"Purified SAC or N-acetyl-SAC; corresponding pharmacokinetic comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; not independent primary verification","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal oral bioavailability exceeded 90%; dog half-life was about 12 hours. These are not human kinetic estimates.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat and dog","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Kidney handling helps explain persistence in blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[25681129] Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25681129/ · DOI 10.1124/dmd.115.063230","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral or intravenous; S9 incubation separately","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aa0f9d79-a2c1-57b4-b94c-7398bc050a76","evidence_kind":"source_excerpt","locator":"Lines 41-48","start_line":41,"end_line":48,"excerpt":"## s-allylcysteine-renal-reabsorption\nKidney handling helps explain persistence in blood.\nVery low renal clearance of SAC, below 0.01 L/h/kg, supported extensive reabsorption in rats and dogs.\nModel: Oral/i.v. pharmacokinetics; liver and kidney S9 experiments\nLimitations: Animal oral bioavailability exceeded 90%; dog half-life was about 12 hours. These are not human kinetic estimates.\nEvidence access: Primary abstract\n[25681129] Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25681129/ · DOI 10.1124/dmd.115.063230\nStructured context: {\"organism\": \"Rat and dog\", \"tissue_or_cell_type\": \"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments\", \"dose\": \"Rats 5 mg/kg; dogs 2 mg/kg\", \"duration\": \"Single administration\", \"route\": \"Oral or intravenous; S9 incubation separately\", \"experimental_comparison\": \"Purified SAC or N-acetyl-SAC; corresponding pharmacokinetic comparisons\", \"acting_entity\": \"s-allylcysteine\", \"interpretation_status\": \"Source-derived research curation; not independent primary verification\"}","model_system":"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3b0d58f9-8a69-579d-9920-518399a9a8bb","stable_key":"import-d96b230c-481b-535b-930c-04eb87ec7f02","title":"S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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