{"id":"e6fd771e-a935-524c-b1c5-6669943d0717","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-benzoate","predicate":"yields_metabolite","statement":"Benzoic acid was identified among the urinary metabolites of administered trans-cinnamaldehyde in rats and mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5bc56afa-6fb9-5652-8cb9-1e7c100577cd","mechanism_event_label":"The aldehyde entered a pathway that produced benzoate.","subject":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"object":{"id":"97b0bcc8-d3f8-5d72-a56a-b7e8d33a50cb","slug":"benzoic-acid","display_name":"Benzoic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"5bc56afa-6fb9-5652-8cb9-1e7c100577cd","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-benzoate-event","event_type":"biochemical_relationship","label":"The aldehyde entered a pathway that produced benzoate.","description":"Benzoic acid was identified among the urinary metabolites of administered trans-cinnamaldehyde in rats and mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"97b0bcc8-d3f8-5d72-a56a-b7e8d33a50cb","slug":"benzoic-acid","display_name":"Benzoic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/7959441.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5bab6bd0ad082e4064c601368d147bfcd87566a98ba749a37974fb1057e8c1be\", \"start_char\": 0, \"end_char\": 1564, \"text_sha256\": \"5bab6bd0ad082e4064c601368d147bfcd87566a98ba749a37974fb1057e8c1be\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Radiolabeled disposition experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2 or 250 mg/kg intraperitoneal, with an additional 250 mg/kg oral arm","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High experimental exposures and rodent species; metabolite recovery does not quantify human nutrient demand or identify every enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rats and mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The aldehyde entered a pathway that produced benzoate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p7959441] Studies on trans-cinnamaldehyde. 1. The influence of dose size and sex on its disposition in the rat and mouse. 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The influence of dose size and sex on its disposition in the rat and mouse. (1994). https://pubmed.ncbi.nlm.nih.gov/7959441/ DOI: 10.1016/0278-6915(94)90084-1","model_system":"Radiolabeled disposition experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p7959441] Studies on trans-cinnamaldehyde. 1. The influence of dose size and sex on its disposition in the rat and mouse. 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