{"id":"e6cb7c48-f08e-540a-935a-cc449c956fab","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-syn-escape-nis","predicate":"reduces_expression","statement":"Rats given 0.05% NaI in drinking water had lower thyroid NIS mRNA and protein at both 1 and 6 days.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d3752971-ceda-5b14-8afa-fd350641e6ad","mechanism_event_label":"Sustained excess iodide reduced the thyroid uptake machinery in rats.","subject":{"id":"e886c46c-651f-5e31-a875-9665c20a2e13","slug":"sodium-iodide","display_name":"Sodium iodide","entity_type_key":"chemical_species"},"object":{"id":"acfbc5ec-b299-5365-8c5d-9e492c18d1d9","slug":"rat-slc5a5","display_name":"Rat sodium/iodide symporter / Slc5a5","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"d3752971-ceda-5b14-8afa-fd350641e6ad","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-syn-escape-nis-event","event_type":"biochemical_relationship","label":"Sustained excess iodide reduced the thyroid uptake machinery in rats.","description":"Rats given 0.05% NaI in drinking water had lower thyroid NIS mRNA and protein at both 1 and 6 days.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"excess_anion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"acfbc5ec-b299-5365-8c5d-9e492c18d1d9","slug":"rat-slc5a5","display_name":"Rat sodium/iodide symporter / Slc5a5","entity_type_key":"protein"},"role":"measured_protein","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e886c46c-651f-5e31-a875-9665c20a2e13","slug":"sodium-iodide","display_name":"Sodium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iodine-synthesis-sources/10433193.json\", \"json_field\": \"abstractText\", \"text_sha256\": \"edf82df926d65731111d3f6b8005965a95e9928421170aa4cb5cef0709adc924\", \"text_characters\": 2339, \"note\": \"Exact publisher passage retained in the cited local source cache; locator and digest supplied here.\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat oral and intraperitoneal sodium iodide experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0.05% sodium iodide in drinking water for 1 or 6 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression data support an escape mechanism but do not independently prove NIS reduction sufficient for escape.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sustained excess iodide reduced the thyroid uptake machinery in rats.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-syn-escape1999] Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. (1999). https://pubmed.ncbi.nlm.nih.gov/10433193/ DOI: 10.1210/endo.140.8.6893","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thyroid","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"57a526be-f7ea-565c-8584-990ed8913256","evidence_kind":"source_excerpt","locator":"Lines 772-784","start_line":772,"end_line":784,"excerpt":"### iodine-syn-escape-nis\nRats given 0.05% NaI in drinking water had lower thyroid NIS mRNA and protein at both 1 and 6 days.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Sustained excess iodide reduced the thyroid uptake machinery in rats.\norganism: Rattus norvegicus\ntissue_or_cell_type: Thyroid\nexperimental_model: Rat oral and intraperitoneal sodium iodide experiments\nlimitations: Expression data support an escape mechanism but do not independently prove NIS reduction sufficient for escape.\nexposure: 0.05% sodium iodide in drinking water for 1 or 6 days.\ncross_nutrient: false\nevidence_span: {\"source_cache\": \"artifacts/iodine-synthesis-sources/10433193.json\", \"json_field\": \"abstractText\", \"text_sha256\": \"edf82df926d65731111d3f6b8005965a95e9928421170aa4cb5cef0709adc924\", \"text_characters\": 2339, \"note\": \"Exact publisher passage retained in the cited local source cache; locator and digest supplied here.\"}\n[iodine-syn-escape1999] Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. 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