{"id":"e6c7fe00-9513-5654-93c5-4050a121dfaf","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-oxidase-null","predicate":"does_not_reduce","statement":"Astaxanthin did not reduce NADPH oxidase activity in the AGS study, unlike the oxidase inhibitor comparator.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"7b60ce29-84eb-5922-aefd-79b3fe34111a","mechanism_event_label":"Lower ROS did not mean this ROS-generating enzyme had been switched off.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"c59cc1db-54f5-5b35-b370-0013d0ff9c7f","slug":"human-astaxanthin-gastric-oxidase","display_name":"NADPH oxidase activity in H. pylori-challenged human AGS cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7b60ce29-84eb-5922-aefd-79b3fe34111a","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-oxidase-null-event","event_type":"observed_relationship","label":"Lower ROS did not mean this ROS-generating enzyme had been switched off.","description":"Astaxanthin did not reduce NADPH oxidase activity in the AGS study, unlike the oxidase inhibitor comparator.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c59cc1db-54f5-5b35-b370-0013d0ff9c7f","slug":"human-astaxanthin-gastric-oxidase","display_name":"NADPH oxidase activity in H. pylori-challenged human AGS cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human AGS cells challenged by H. pylori.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer a universal NADPH-oxidase-inhibition mechanism from lower ROS.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Lower ROS did not mean this ROS-generating enzyme had been switched off.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dd419879-0f9a-53f5-b851-652fb021995e","evidence_kind":"source_excerpt","locator":"Lines 310-316","start_line":310,"end_line":316,"excerpt":"## astaxanthin-gastric-oxidase-null\nLower ROS did not mean this ROS-generating enzyme had been switched off.\nAstaxanthin did not reduce NADPH oxidase activity in the AGS study, unlike the oxidase inhibitor comparator.\nModel: Human AGS cells challenged by H. pylori.\nLimitations: Do not infer a universal NADPH-oxidase-inhibition mechanism from lower ROS.\nEvidence access: Primary abstract\nAstaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","model_system":"Human AGS cells challenged by H. pylori.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}