{"id":"e66b2a18-a17b-5d25-adab-e162cddec6d7","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-bilophila","predicate":"feeding_expands","statement":"Adding taurocholic acid, but not glycocholic acid, to a low-fat mouse diet promoted Bilophila wadsworthia expansion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6224e72e-c262-5b9b-a6e1-2df514e02d31","mechanism_event_label":"Taurine-conjugated bile supplies sulfur that certain microbes can exploit.","subject":{"id":"4f4ae3d8-b415-53b7-8262-46d90815a0c9","slug":"taurocholate","display_name":"Taurocholate","entity_type_key":"small_molecule"},"object":{"id":"fdce898d-e08b-5e90-9fcf-1613df00619f","slug":"mouse-bilophila-expansion","display_name":"Bilophila expansion in the milk-fat/taurocholate mouse experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6224e72e-c262-5b9b-a6e1-2df514e02d31","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-bilophila-event","event_type":"observed_relationship","label":"Taurine-conjugated bile supplies sulfur that certain microbes can exploit.","description":"Adding taurocholic acid, but not glycocholic acid, to a low-fat mouse diet promoted Bilophila wadsworthia expansion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4f4ae3d8-b415-53b7-8262-46d90815a0c9","slug":"taurocholate","display_name":"Taurocholate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fdce898d-e08b-5e90-9fcf-1613df00619f","slug":"mouse-bilophila-expansion","display_name":"Bilophila expansion in the milk-fat/taurocholate mouse experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d4efdf7e-a484-5c49-a89a-e76975139b52","slug":"bilophila-wadsworthia","display_name":"Bilophila wadsworthia","entity_type_key":"organism"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"be9d8bde-6521-5b10-8517-5bd8d7826b12","slug":"glycocholate","display_name":"Glycocholate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse dietary experiments with conjugate comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The intervention was taurocholate, not free taurine alone; microbial community and host genotype matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Taurine-conjugated bile supplies sulfur that certain microbes can exploit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22722865/ · DOI 10.1038/nature11225","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"43019a63-d8a9-5bd0-ba9a-b7f0b8df03da","evidence_kind":"source_excerpt","locator":"Lines 329-335","start_line":329,"end_line":335,"excerpt":"## taurine-microbial-bilophila\nTaurine-conjugated bile supplies sulfur that certain microbes can exploit.\nAdding taurocholic acid, but not glycocholic acid, to a low-fat mouse diet promoted Bilophila wadsworthia expansion.\nModel: Mouse dietary experiments with conjugate comparison.\nLimitations: The intervention was taurocholate, not free taurine alone; microbial community and host genotype matter.\nEvidence access: Primary abstract\nDietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22722865/ · DOI 10.1038/nature11225","model_system":"Mouse dietary experiments with conjugate comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}