{"id":"e6698649-efd7-55f1-9c8e-a40ad7240474","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-muscle-mito","predicate":"preserves_in_atrophy_model","statement":"DIM limited the loss of mitochondrial membrane potential and excessive ROS generation in the atrophy models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"291483cc-5a0a-5ac0-b8d4-65a821581ebf","mechanism_event_label":"Mitochondrial measurements improved in this preclinical setting.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"2f9332e0-0138-5e42-8c7b-8f8f45615782","slug":"mitochondrial-membrane-potential","display_name":"Inner mitochondrial membrane potential","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"291483cc-5a0a-5ac0-b8d4-65a821581ebf","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-muscle-mito-event","event_type":"biochemical_relationship","label":"Mitochondrial measurements improved in this preclinical setting.","description":"DIM limited the loss of mitochondrial membrane potential and excessive ROS generation in the atrophy models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"32436d21-5a81-59af-951a-16c619288007","slug":"cellular-ros-signal","display_name":"Cellular reactive-oxygen-species assay signal","entity_type_key":"cellular_process"},"role":"reduced_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2f9332e0-0138-5e42-8c7b-8f8f45615782","slug":"mitochondrial-membrane-potential","display_name":"Inner mitochondrial membrane potential","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/42308990.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\", \"start_char\": 0, \"end_char\": 2803, \"text_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dexamethasone atrophy and aging-model experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"DIM in experimental atrophy/aging models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"2026 preclinical study, not a human sarcopenia trial. Mouse STIM1 stays distinct from the human selenium-linked STIM1 record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mouse muscle, mouse C2C12 myotubes and C. elegans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Mitochondrial measurements improved in this preclinical setting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p42308990] 3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis. 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Mouse STIM1 stays distinct from the human selenium-linked STIM1 record.\nexposure: DIM in experimental atrophy/aging models\nevidence_span: {\"source_cache\": \"artifacts/dim-research/42308990.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\", \"start_char\": 0, \"end_char\": 2803, \"text_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\"}\n[dim-p42308990] 3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308990/ DOI: 10.1016/j.phymed.2026.158409","model_system":"Dexamethasone atrophy and aging-model experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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