{"id":"e6532f06-722f-5cb0-a1e9-efe192b9c7d4","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-tasl-bypass","predicate":"rescues_tested","statement":"Artificially tethering TASL to endolysosomes restored TLR7-9-induced IRF5 activation and interferon/cytokine production in SLC15A4-deficient human cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7cbb55a3-f5d4-5132-bdc0-b0e8087696aa","mechanism_event_label":"A targeted scaffold bypass restored signaling without the transporter.","subject":{"id":"82eae972-7da8-5908-bfd7-1d3c73e869ec","slug":"tasl","display_name":"Human TLR adaptor interacting with SLC15A4 / TASL","entity_type_key":"protein"},"object":{"id":"c3fd75a1-e1a0-5c88-bc2d-c14522bf91c7","slug":"human-endolysosomal-tlr-irf-output","display_name":"Human endolysosomal TLR IRF signaling","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7cbb55a3-f5d4-5132-bdc0-b0e8087696aa","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-tasl-bypass-event","event_type":"observed_relationship","label":"A targeted scaffold bypass restored signaling without the transporter.","description":"Artificially tethering TASL to endolysosomes restored TLR7-9-induced IRF5 activation and interferon/cytokine production in SLC15A4-deficient human cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82eae972-7da8-5908-bfd7-1d3c73e869ec","slug":"tasl","display_name":"Human TLR adaptor interacting with SLC15A4 / TASL","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c3fd75a1-e1a0-5c88-bc2d-c14522bf91c7","slug":"human-endolysosomal-tlr-irf-output","display_name":"Human endolysosomal TLR IRF signaling","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"eca38509-73b3-5fc5-be33-2fa6d60ed1bb","slug":"slc15a4","display_name":"Human peptide/histidine transporter PHT1 / SLC15A4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"0f2e1ba6-30ca-5b3f-9876-41572817fdd3","slug":"irf5","display_name":"Human interferon regulatory factor 5 / IRF5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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